Matches in SemOpenAlex for { <https://semopenalex.org/work/W2440492077> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2440492077 endingPage "9" @default.
- W2440492077 startingPage "313" @default.
- W2440492077 abstract "The aim of this study was to evaluate preventive effects of raloxifene (RAL), melatonin (MEL) and their combination in N-methyl-N-nitrosourea (NMU)-induced rat mammary carcinogenesis. MEL-treatment began 12 days and RAL treatment began 10 days prior to carcinogen administration and continued till the end of experiment (24 weeks after first carcinogen administration). RAL was administered subcutaneously twice a week in the dose of 5 mg/kg b.w. MEL was administered diluted in drinking water in a concentration 4 microg/ml daily from 3 p.m. to 8 a.m. At the end of experiment, tumor incidence, frequency, latency period and tumor volume as parameters of mammary carcinogenesis were evaluated. Moreover, the effect of chemopreventives on body and uterine weight, food and water intake were recorded. In RAL-treated group, tumor incidence was decreased by 67% (p < 0.001), tumor frequency per group was reduced by 90% (p < 0.0002) and latency period lengthened by 27 days in comparison with control group. After MEL-treatment tumor incidence was decreased by 19%, tumor frequency per group was decreased by 50% (p < 0.05) when compared to control animals. The effect of RAL+MEL-treatment was very similar to that of RAL-treatment. In groups with RAL administration, significant decrease (p < 0.0001) in body weight gain and relative uterine weight was recorded. As to food intake no significant differences in comparison with control group were found. Consequently, groups were pooled and in RAL-treated groups (RAL, RAL+MEL) a decrease in food intake, when compared to groups without RAL administration (control group, MEL) was recorded (p<0.04). The water intake was markedly decreased in RAL-treated groups (P < 0.0001). RAL and RAL+MEL proved to be very effective in prevention of experimental mammary carcinogenesis in female rats, isolated MEL appeared to be of lower oncostatic activity." @default.
- W2440492077 created "2016-06-24" @default.
- W2440492077 creator A5000050616 @default.
- W2440492077 creator A5002813572 @default.
- W2440492077 creator A5008547057 @default.
- W2440492077 creator A5041231632 @default.
- W2440492077 creator A5047384545 @default.
- W2440492077 creator A5066851622 @default.
- W2440492077 creator A5077691774 @default.
- W2440492077 creator A5082347476 @default.
- W2440492077 date "2001-01-01" @default.
- W2440492077 modified "2023-09-27" @default.
- W2440492077 title "Preventive effects of raloxifene and melatonin in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats." @default.
- W2440492077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11712685" @default.
- W2440492077 hasPublicationYear "2001" @default.
- W2440492077 type Work @default.
- W2440492077 sameAs 2440492077 @default.
- W2440492077 citedByCount "2" @default.
- W2440492077 crossrefType "journal-article" @default.
- W2440492077 hasAuthorship W2440492077A5000050616 @default.
- W2440492077 hasAuthorship W2440492077A5002813572 @default.
- W2440492077 hasAuthorship W2440492077A5008547057 @default.
- W2440492077 hasAuthorship W2440492077A5041231632 @default.
- W2440492077 hasAuthorship W2440492077A5047384545 @default.
- W2440492077 hasAuthorship W2440492077A5066851622 @default.
- W2440492077 hasAuthorship W2440492077A5077691774 @default.
- W2440492077 hasAuthorship W2440492077A5082347476 @default.
- W2440492077 hasConcept C114246631 @default.
- W2440492077 hasConcept C121608353 @default.
- W2440492077 hasConcept C126322002 @default.
- W2440492077 hasConcept C134018914 @default.
- W2440492077 hasConcept C143590678 @default.
- W2440492077 hasConcept C147583825 @default.
- W2440492077 hasConcept C178790620 @default.
- W2440492077 hasConcept C185592680 @default.
- W2440492077 hasConcept C2776187077 @default.
- W2440492077 hasConcept C2777176818 @default.
- W2440492077 hasConcept C2778182776 @default.
- W2440492077 hasConcept C2779889926 @default.
- W2440492077 hasConcept C530470458 @default.
- W2440492077 hasConcept C555283112 @default.
- W2440492077 hasConcept C71924100 @default.
- W2440492077 hasConceptScore W2440492077C114246631 @default.
- W2440492077 hasConceptScore W2440492077C121608353 @default.
- W2440492077 hasConceptScore W2440492077C126322002 @default.
- W2440492077 hasConceptScore W2440492077C134018914 @default.
- W2440492077 hasConceptScore W2440492077C143590678 @default.
- W2440492077 hasConceptScore W2440492077C147583825 @default.
- W2440492077 hasConceptScore W2440492077C178790620 @default.
- W2440492077 hasConceptScore W2440492077C185592680 @default.
- W2440492077 hasConceptScore W2440492077C2776187077 @default.
- W2440492077 hasConceptScore W2440492077C2777176818 @default.
- W2440492077 hasConceptScore W2440492077C2778182776 @default.
- W2440492077 hasConceptScore W2440492077C2779889926 @default.
- W2440492077 hasConceptScore W2440492077C530470458 @default.
- W2440492077 hasConceptScore W2440492077C555283112 @default.
- W2440492077 hasConceptScore W2440492077C71924100 @default.
- W2440492077 hasIssue "4" @default.
- W2440492077 hasLocation W24404920771 @default.
- W2440492077 hasOpenAccess W2440492077 @default.
- W2440492077 hasPrimaryLocation W24404920771 @default.
- W2440492077 hasRelatedWork W1922101533 @default.
- W2440492077 hasRelatedWork W1999186466 @default.
- W2440492077 hasRelatedWork W2076384522 @default.
- W2440492077 hasRelatedWork W2167633620 @default.
- W2440492077 hasRelatedWork W2345727187 @default.
- W2440492077 hasRelatedWork W2402694658 @default.
- W2440492077 hasRelatedWork W2403843412 @default.
- W2440492077 hasRelatedWork W2418242023 @default.
- W2440492077 hasRelatedWork W2440492077 @default.
- W2440492077 hasRelatedWork W4245151279 @default.
- W2440492077 hasVolume "48" @default.
- W2440492077 isParatext "false" @default.
- W2440492077 isRetracted "false" @default.
- W2440492077 magId "2440492077" @default.
- W2440492077 workType "article" @default.