Matches in SemOpenAlex for { <https://semopenalex.org/work/W2440521380> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2440521380 endingPage "L593" @default.
- W2440521380 startingPage "L586" @default.
- W2440521380 abstract "Extracellular ATP (10(-3) M) stimulated [3H]phosphatidylcholine secretion approximately 3.4-fold in rat type II pneumocytes prelabeled overnight with [3H]choline. The same concentration of ATP caused a rapid increase in [3H]inositol trisphosphate (IP3) and a decrease in [3H]phosphatidylinositol bisphosphate (PIP2) in [3H]inositol-prelabeled cells. ATP also caused a biphasic increase in 1,2-[3H]diacylglycerol in cells prelabeled with [3H]arachidonic acid: a rapid increase that peaked at 10 s followed by a larger increase that peaked at 5-10 min. The first peak in diacylglycerol and the increase in IP3 are consistent with phospholipase C action on PIP2 and generation of second messengers that promote mobilization of intracellular Ca2+ and activation of protein kinase C. However, at the level of phosphatidylcholine secretion the stimulatory effects of ATP and of direct activators of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 1,2-dioctanoyl-sn-glycerol, were at least additive, suggesting that activation of protein kinase C may not be the major signal transduction mechanism in ATP action or alternatively that ATP activates a different isoform of protein kinase C. Pretreatment of type II cells with TPA for 30 min led to a subsequent 40% diminution in the stimulatory effects of ATP on both phosphatidylcholine secretion and IP3 generation." @default.
- W2440521380 created "2016-06-24" @default.
- W2440521380 creator A5026513074 @default.
- W2440521380 creator A5065547785 @default.
- W2440521380 creator A5072400402 @default.
- W2440521380 date "1991-06-01" @default.
- W2440521380 modified "2023-09-27" @default.
- W2440521380 title "ATP-stimulated inositol phospholipid metabolism and surfactant secretion in rat type II pneumocytes" @default.
- W2440521380 doi "https://doi.org/10.1152/ajplung.1991.260.6.l586" @default.
- W2440521380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1647684" @default.
- W2440521380 hasPublicationYear "1991" @default.
- W2440521380 type Work @default.
- W2440521380 sameAs 2440521380 @default.
- W2440521380 citedByCount "20" @default.
- W2440521380 countsByYear W24405213802016 @default.
- W2440521380 countsByYear W24405213802018 @default.
- W2440521380 countsByYear W24405213802020 @default.
- W2440521380 crossrefType "journal-article" @default.
- W2440521380 hasAuthorship W2440521380A5026513074 @default.
- W2440521380 hasAuthorship W2440521380A5065547785 @default.
- W2440521380 hasAuthorship W2440521380A5072400402 @default.
- W2440521380 hasConcept C163235415 @default.
- W2440521380 hasConcept C170493617 @default.
- W2440521380 hasConcept C181199279 @default.
- W2440521380 hasConcept C184235292 @default.
- W2440521380 hasConcept C195794163 @default.
- W2440521380 hasConcept C2776330855 @default.
- W2440521380 hasConcept C2776387844 @default.
- W2440521380 hasConcept C2776909261 @default.
- W2440521380 hasConcept C2777427919 @default.
- W2440521380 hasConcept C2778078955 @default.
- W2440521380 hasConcept C2778597717 @default.
- W2440521380 hasConcept C2778618036 @default.
- W2440521380 hasConcept C2778918659 @default.
- W2440521380 hasConcept C2780610907 @default.
- W2440521380 hasConcept C2781387506 @default.
- W2440521380 hasConcept C36020004 @default.
- W2440521380 hasConcept C41625074 @default.
- W2440521380 hasConcept C49039625 @default.
- W2440521380 hasConcept C55493867 @default.
- W2440521380 hasConcept C62478195 @default.
- W2440521380 hasConcept C86803240 @default.
- W2440521380 hasConceptScore W2440521380C163235415 @default.
- W2440521380 hasConceptScore W2440521380C170493617 @default.
- W2440521380 hasConceptScore W2440521380C181199279 @default.
- W2440521380 hasConceptScore W2440521380C184235292 @default.
- W2440521380 hasConceptScore W2440521380C195794163 @default.
- W2440521380 hasConceptScore W2440521380C2776330855 @default.
- W2440521380 hasConceptScore W2440521380C2776387844 @default.
- W2440521380 hasConceptScore W2440521380C2776909261 @default.
- W2440521380 hasConceptScore W2440521380C2777427919 @default.
- W2440521380 hasConceptScore W2440521380C2778078955 @default.
- W2440521380 hasConceptScore W2440521380C2778597717 @default.
- W2440521380 hasConceptScore W2440521380C2778618036 @default.
- W2440521380 hasConceptScore W2440521380C2778918659 @default.
- W2440521380 hasConceptScore W2440521380C2780610907 @default.
- W2440521380 hasConceptScore W2440521380C2781387506 @default.
- W2440521380 hasConceptScore W2440521380C36020004 @default.
- W2440521380 hasConceptScore W2440521380C41625074 @default.
- W2440521380 hasConceptScore W2440521380C49039625 @default.
- W2440521380 hasConceptScore W2440521380C55493867 @default.
- W2440521380 hasConceptScore W2440521380C62478195 @default.
- W2440521380 hasConceptScore W2440521380C86803240 @default.
- W2440521380 hasIssue "6" @default.
- W2440521380 hasLocation W24405213801 @default.
- W2440521380 hasLocation W24405213802 @default.
- W2440521380 hasOpenAccess W2440521380 @default.
- W2440521380 hasPrimaryLocation W24405213801 @default.
- W2440521380 hasRelatedWork W1527037471 @default.
- W2440521380 hasRelatedWork W1680355598 @default.
- W2440521380 hasRelatedWork W198784161 @default.
- W2440521380 hasRelatedWork W2067990309 @default.
- W2440521380 hasRelatedWork W2070986848 @default.
- W2440521380 hasRelatedWork W2342778994 @default.
- W2440521380 hasRelatedWork W2404365298 @default.
- W2440521380 hasRelatedWork W2410875189 @default.
- W2440521380 hasRelatedWork W304974330 @default.
- W2440521380 hasRelatedWork W4256104342 @default.
- W2440521380 hasVolume "260" @default.
- W2440521380 isParatext "false" @default.
- W2440521380 isRetracted "false" @default.
- W2440521380 magId "2440521380" @default.
- W2440521380 workType "article" @default.