Matches in SemOpenAlex for { <https://semopenalex.org/work/W2440692722> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2440692722 endingPage "80" @default.
- W2440692722 startingPage "769" @default.
- W2440692722 abstract "Acute limb ischaemia (ALI) is a serious medical emergency leading to high rate of complications, being not only limb- but even life-threatening, often in spite of early successful revascularization. Concomitant underlying diseases, the metabolic derangement that seems a result of the acute insult and a possible reperfusion injury following revascularization may account for this severe prognosis. Only anticoagulation, fasciotomy and perioperative supportive treatment are established strategies in ALI patients. Possible benefit from chronic therapies active on vascular and cardiac side has been suggested. Moreover, several categories of compounds, potentially acting on pathophysiological mechanisms of ischemia-reperfusion syndrome, have been tested in experimental models, but none of them has as yet been proven effective in clinical studies. Prostanoids are drugs traditionally utilized in critical chronic limb ischaemia, and their pharmacological properties support a potential usefulness as adjuvant treatment in ALI. In a pilot double-blind placebo-controlled study it has been evaluated the effect of perioperative iloprost, a synthetic prostacyclin analogue, in 30 patients with ALI undergoing Fogarty's thromboembolectomy. The encouraging results of iloprost in this study (lower incidence of major clinical events, more evident metabolic improvement by means of transcutaneous tensiometry--statistically significant reduction in TcpCO2--suggested the opportunity of performing a larger, multicenter trial (ILAILL). In comparison with the pilot study, ILAILL included patients undergoing various types of surgical revascularization, and a longer period of experimental treatment and post-operative follow-up. Preliminary data from this study confirm the high morbidity and mortality of ALI (overall incidence of major events, 29%). Results of ILAILL trial, as for comparison of effects between iloprost and control group, will be available at the beginning of 2005." @default.
- W2440692722 created "2016-06-24" @default.
- W2440692722 creator A5001840951 @default.
- W2440692722 creator A5004599835 @default.
- W2440692722 date "2005-03-18" @default.
- W2440692722 modified "2023-09-23" @default.
- W2440692722 title "Is it possible to improve outcome in patients undergoing surgery for acute limb ischemia? Can iloprost, a prostacyclin analogue, be helpful?" @default.
- W2440692722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15771029" @default.
- W2440692722 hasPublicationYear "2005" @default.
- W2440692722 type Work @default.
- W2440692722 sameAs 2440692722 @default.
- W2440692722 citedByCount "2" @default.
- W2440692722 countsByYear W24406927222019 @default.
- W2440692722 crossrefType "journal-article" @default.
- W2440692722 hasAuthorship W2440692722A5001840951 @default.
- W2440692722 hasAuthorship W2440692722A5004599835 @default.
- W2440692722 hasConcept C126322002 @default.
- W2440692722 hasConcept C141071460 @default.
- W2440692722 hasConcept C142724271 @default.
- W2440692722 hasConcept C177713679 @default.
- W2440692722 hasConcept C204787440 @default.
- W2440692722 hasConcept C27081682 @default.
- W2440692722 hasConcept C2776204877 @default.
- W2440692722 hasConcept C2779464278 @default.
- W2440692722 hasConcept C2781103887 @default.
- W2440692722 hasConcept C2781128415 @default.
- W2440692722 hasConcept C31174226 @default.
- W2440692722 hasConcept C42219234 @default.
- W2440692722 hasConcept C500558357 @default.
- W2440692722 hasConcept C541997718 @default.
- W2440692722 hasConcept C71924100 @default.
- W2440692722 hasConceptScore W2440692722C126322002 @default.
- W2440692722 hasConceptScore W2440692722C141071460 @default.
- W2440692722 hasConceptScore W2440692722C142724271 @default.
- W2440692722 hasConceptScore W2440692722C177713679 @default.
- W2440692722 hasConceptScore W2440692722C204787440 @default.
- W2440692722 hasConceptScore W2440692722C27081682 @default.
- W2440692722 hasConceptScore W2440692722C2776204877 @default.
- W2440692722 hasConceptScore W2440692722C2779464278 @default.
- W2440692722 hasConceptScore W2440692722C2781103887 @default.
- W2440692722 hasConceptScore W2440692722C2781128415 @default.
- W2440692722 hasConceptScore W2440692722C31174226 @default.
- W2440692722 hasConceptScore W2440692722C42219234 @default.
- W2440692722 hasConceptScore W2440692722C500558357 @default.
- W2440692722 hasConceptScore W2440692722C541997718 @default.
- W2440692722 hasConceptScore W2440692722C71924100 @default.
- W2440692722 hasIssue "6" @default.
- W2440692722 hasLocation W24406927221 @default.
- W2440692722 hasOpenAccess W2440692722 @default.
- W2440692722 hasPrimaryLocation W24406927221 @default.
- W2440692722 hasRelatedWork W1964601006 @default.
- W2440692722 hasRelatedWork W2027514096 @default.
- W2440692722 hasRelatedWork W2047967234 @default.
- W2440692722 hasRelatedWork W2088734405 @default.
- W2440692722 hasRelatedWork W2403869361 @default.
- W2440692722 hasRelatedWork W2416195698 @default.
- W2440692722 hasRelatedWork W2440692722 @default.
- W2440692722 hasRelatedWork W2889303257 @default.
- W2440692722 hasRelatedWork W2903633353 @default.
- W2440692722 hasRelatedWork W2944903501 @default.
- W2440692722 hasVolume "56" @default.
- W2440692722 isParatext "false" @default.
- W2440692722 isRetracted "false" @default.
- W2440692722 magId "2440692722" @default.
- W2440692722 workType "article" @default.