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• W2440771818 abstract "Long noncoding RNAs (lncRNAs) play multiple key regulatory roles in various cellular pathways. However, their functions in HIV-1 latent infection remain largely unknown. Here we show that a lncRNA named NRON, which is highly expressed in resting CD4(+) T lymphocytes, could be involved in HIV-1 latency by specifically inducing Tat protein degradation. Our results suggest that NRON lncRNA potently suppresses the viral transcription by decreasing the cellular abundance of viral transactivator protein Tat. NRON directly links Tat to the ubiquitin/proteasome components including CUL4B and PSMD11, thus facilitating Tat degradation. Depletion of NRON, especially in combination with a histone deacetylase (HDAC) inhibitor, significantly reactivates the viral production from the HIV-1-latently infected primary CD4(+) T lymphocytes. Our data indicate that lncRNAs play a role in HIV-1 latency and their manipulation could be a novel approach for developing latency-reversing agents." @default.
• W2440771818 created "2016-06-24" @default.
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• W2440771818 creator A5074053393 @default.
• W2440771818 creator A5089169152 @default.
• W2440771818 date "2016-06-13" @default.
• W2440771818 modified "2023-10-14" @default.
• W2440771818 title "Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation" @default.
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• W2440771818 doi "https://doi.org/10.1038/ncomms11730" @default.
• W2440771818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4909936" @default.
• W2440771818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27291871" @default.
• W2440771818 hasPublicationYear "2016" @default.
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