FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2440952913> ?p ?o ?g. }

• W2440952913 endingPage "16988" @default.
• W2440952913 startingPage "16983" @default.
• W2440952913 abstract "Previous evidence indicates that, in carriers of apolipoprotein E4 (ApoE4), estrogen therapy increased the risk of late-onset Alzheimer's disease (AD), whereas in individuals carrying ApoE2/3, estrogen therapy reduced the risk of AD [Cauley JA, Zmuda JM, Yaffe K, Kuller LH, Ferrell RE, Wisniewski SR, Cummings SR (1999) J Bone Miner Res 14:1175-1181; Yaffe K, Haan M, Byers A, Tangen C, Kuller L (2000) Neurology 54:1949-1954]. Estrogen mechanisms of action are mediated by two estrogen receptors (ERs), ERalpha and ERbeta. In this study, we determined the relationship between ER subtype and estrogen regulation of ApoE expression in HT-22 cells ectopically transfected with ERalpha or ERbeta, in primary cultured rat hippocampal neurons in vitro and in rat hippocampus in vivo by both molecular biological and pharmacological analyses. Results of these analyses demonstrated that activation of ERalpha either by 17beta-estradiol or a specific-agonist, propylpyrazole triol, up-regulated ApoE mRNA and protein expression. In contrast, the ERbeta-selective agonist, diarylpropionitrile, down-regulated ApoE mRNA and protein expression. These results demonstrate that, in vitro and in vivo, ApoE expression can be differentially regulated depending on activation of ER subtypes. These data suggest that use of ER-selective ligands could provide therapeutic benefit to reduce the risk of AD by increasing ApoE expression in ApoE2/3 allele carriers and decreasing ApoE expression in ApoE4 allele carriers." @default.
• W2440952913 created "2016-06-24" @default.
• W2440952913 creator A5005920250 @default.
• W2440952913 creator A5010711713 @default.
• W2440952913 creator A5040036109 @default.
• W2440952913 date "2006-11-07" @default.
• W2440952913 modified "2023-10-18" @default.
• W2440952913 title "Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus <i>in vitro</i> and <i>in vivo</i>" @default.
• W2440952913 cites W143363706 @default.
• W2440952913 cites W1460005622 @default.
• W2440952913 cites W1497692202 @default.
• W2440952913 cites W1932154717 @default.
• W2440952913 cites W1965834391 @default.
• W2440952913 cites W1966593898 @default.
• W2440952913 cites W1976700967 @default.
• W2440952913 cites W1984737558 @default.
• W2440952913 cites W1985815862 @default.
• W2440952913 cites W1986324285 @default.
• W2440952913 cites W1986973693 @default.
• W2440952913 cites W1988899624 @default.
• W2440952913 cites W1993121285 @default.
• W2440952913 cites W1997913988 @default.
• W2440952913 cites W2000913322 @default.
• W2440952913 cites W2003527151 @default.
• W2440952913 cites W2003588514 @default.
• W2440952913 cites W2004602458 @default.
• W2440952913 cites W2006292630 @default.
• W2440952913 cites W2006376420 @default.
• W2440952913 cites W2011837326 @default.
• W2440952913 cites W2021449355 @default.
• W2440952913 cites W2021454655 @default.
• W2440952913 cites W2024477210 @default.
• W2440952913 cites W2024616809 @default.
• W2440952913 cites W2028820486 @default.
• W2440952913 cites W2028871486 @default.
• W2440952913 cites W2035261428 @default.
• W2440952913 cites W2035589234 @default.
• W2440952913 cites W2037354720 @default.
• W2440952913 cites W2044241508 @default.
• W2440952913 cites W2044774078 @default.
• W2440952913 cites W2056735634 @default.
• W2440952913 cites W2056822801 @default.
• W2440952913 cites W2061148596 @default.
• W2440952913 cites W2061916198 @default.
• W2440952913 cites W2064501387 @default.
• W2440952913 cites W2066644955 @default.
• W2440952913 cites W2068377076 @default.
• W2440952913 cites W2084983915 @default.
• W2440952913 cites W2086036750 @default.
• W2440952913 cites W2088655169 @default.
• W2440952913 cites W2089676562 @default.
• W2440952913 cites W2094425964 @default.
• W2440952913 cites W2109137609 @default.
• W2440952913 cites W2109666614 @default.
• W2440952913 cites W2111441108 @default.
• W2440952913 cites W2112152476 @default.
• W2440952913 cites W2119791710 @default.
• W2440952913 cites W2122197695 @default.
• W2440952913 cites W2123424905 @default.
• W2440952913 cites W2127129379 @default.
• W2440952913 cites W2127778297 @default.
• W2440952913 cites W2131066059 @default.
• W2440952913 cites W2144924184 @default.
• W2440952913 cites W2147413218 @default.
• W2440952913 cites W2149088240 @default.
• W2440952913 cites W2154937055 @default.
• W2440952913 cites W2156965301 @default.
• W2440952913 cites W2158965128 @default.
• W2440952913 cites W2163922745 @default.
• W2440952913 cites W2169892526 @default.
• W2440952913 cites W2171891799 @default.
• W2440952913 cites W2203790941 @default.
• W2440952913 cites W4210821588 @default.
• W2440952913 doi "https://doi.org/10.1073/pnas.0608128103" @default.
• W2440952913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1636565" @default.
• W2440952913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17077142" @default.
• W2440952913 hasPublicationYear "2006" @default.
• W2440952913 type Work @default.
• W2440952913 sameAs 2440952913 @default.
• W2440952913 citedByCount "86" @default.
• W2440952913 countsByYear W24409529132012 @default.
• W2440952913 countsByYear W24409529132013 @default.
• W2440952913 countsByYear W24409529132014 @default.
• W2440952913 countsByYear W24409529132015 @default.
• W2440952913 countsByYear W24409529132016 @default.
• W2440952913 countsByYear W24409529132017 @default.
• W2440952913 countsByYear W24409529132018 @default.
• W2440952913 countsByYear W24409529132019 @default.
• W2440952913 countsByYear W24409529132020 @default.
• W2440952913 countsByYear W24409529132021 @default.
• W2440952913 countsByYear W24409529132022 @default.
• W2440952913 countsByYear W24409529132023 @default.
• W2440952913 crossrefType "journal-article" @default.
• W2440952913 hasAuthorship W2440952913A5005920250 @default.
• W2440952913 hasAuthorship W2440952913A5010711713 @default.
• W2440952913 hasAuthorship W2440952913A5040036109 @default.
• W2440952913 hasBestOaLocation W24409529131 @default.
• W2440952913 hasConcept C121608353 @default.

• next