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- W2441212635 endingPage "733" @default.
- W2441212635 startingPage "726" @default.
- W2441212635 abstract "Mature spermatozoa are permeable to foreign DNA and RNA molecules. Here I propose a model, whereby extrachromosomal genetic information, mostly encoded in the form of RNA in somatic cells, can cross the Weismann barrier and reach epididymal spermatozoa. LINE‐1 retrotransposon‐derived reverse transcriptase (RT) can play key roles in the process by expanding the RNA‐encoded information. Retrotransposon‐encoded RT is stored in mature gametes, is highly expressed in early embryos and undifferentiated cells, and becomes downregulated in differentiated cells. In turn, RT plays a role in developmental control, as its inhibition arrests developmental progression of early embryos with globally altered transcriptomic profiles. Thus, sperm cells act as recipients, and transgenerational vectors of somatically derived genetic information which they pass to the next generation with the potential to modify the fate of the developing embryos." @default.
- W2441212635 created "2016-06-24" @default.
- W2441212635 creator A5027416476 @default.
- W2441212635 date "2016-06-17" @default.
- W2441212635 modified "2023-10-16" @default.
- W2441212635 title "Soma to germline inheritance of extrachromosomal genetic information via a LINE-1 reverse transcriptase-based mechanism" @default.
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