Matches in SemOpenAlex for { <https://semopenalex.org/work/W2441253660> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2441253660 endingPage "22" @default.
- W2441253660 startingPage "317" @default.
- W2441253660 abstract "The effect of alpha-adrenergic receptor antagonists, phentolamine, and prazosin on cytosolic Ca2+ concentration, [Ca2+]i, was studied in hepatocytes during endotoxic shock. Rats were given intravenous injections of endotoxin (20 mg/kg), phentolamine (3 mg/kg) plus endotoxin (20 mg/kg), or prazosin (5 mg/kg) plus endotoxin (20 mg/kg). They were sacrificed 5 hr later, at which time the endotoxin-injected rats showed signs of shock. Isolated hepatocytes were prepared and employed for the measurement of [Ca2+]i under basal and hormone-stimulated (1 and 10 microM epinephrine) conditions by means of Quin 2 fluorescence technique. The apparent basal level of [Ca2+]i in endotoxic rat hepatocytes (mean +/- SE: 482 +/- 31 nM) was significantly higher (P less than 0.05) than in phentolamine plus endotoxin (242 +/- 73) and prazosin plus endotoxin (240 +/- 43) groups. A significant increase in hepatocyte [Ca2+]i occurred with epinephrine in the phentolamine plus endotoxin and prazosin plus endotoxin groups, but not in the group receiving endotoxin alone. Endotoxic rats showed a mortality rate of 75%, whereas phentolamine plus endotoxin and prazosin plus endotoxin groups showed a mortality rate of 38% and 20% respectively. These data suggest that the protective effect of alpha-adrenergic receptor antagonists during endotoxic shock may be mediated, in part, by attenuating the entrance of Ca2+ into endotoxic liver cells." @default.
- W2441253660 created "2016-06-24" @default.
- W2441253660 creator A5055975685 @default.
- W2441253660 creator A5080510594 @default.
- W2441253660 date "1992-08-01" @default.
- W2441253660 modified "2023-09-23" @default.
- W2441253660 title "Effect of alpha-adrenergic blockage on cellular Ca2+ during endotoxic shock." @default.
- W2441253660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1446390" @default.
- W2441253660 hasPublicationYear "1992" @default.
- W2441253660 type Work @default.
- W2441253660 sameAs 2441253660 @default.
- W2441253660 citedByCount "2" @default.
- W2441253660 countsByYear W24412536602016 @default.
- W2441253660 crossrefType "journal-article" @default.
- W2441253660 hasAuthorship W2441253660A5055975685 @default.
- W2441253660 hasAuthorship W2441253660A5080510594 @default.
- W2441253660 hasConcept C126322002 @default.
- W2441253660 hasConcept C134018914 @default.
- W2441253660 hasConcept C158453852 @default.
- W2441253660 hasConcept C170493617 @default.
- W2441253660 hasConcept C185592680 @default.
- W2441253660 hasConcept C2775859304 @default.
- W2441253660 hasConcept C2776885963 @default.
- W2441253660 hasConcept C2778151854 @default.
- W2441253660 hasConcept C2780253649 @default.
- W2441253660 hasConcept C2780648677 @default.
- W2441253660 hasConcept C2781300812 @default.
- W2441253660 hasConcept C40465926 @default.
- W2441253660 hasConcept C71924100 @default.
- W2441253660 hasConcept C98274493 @default.
- W2441253660 hasConceptScore W2441253660C126322002 @default.
- W2441253660 hasConceptScore W2441253660C134018914 @default.
- W2441253660 hasConceptScore W2441253660C158453852 @default.
- W2441253660 hasConceptScore W2441253660C170493617 @default.
- W2441253660 hasConceptScore W2441253660C185592680 @default.
- W2441253660 hasConceptScore W2441253660C2775859304 @default.
- W2441253660 hasConceptScore W2441253660C2776885963 @default.
- W2441253660 hasConceptScore W2441253660C2778151854 @default.
- W2441253660 hasConceptScore W2441253660C2780253649 @default.
- W2441253660 hasConceptScore W2441253660C2780648677 @default.
- W2441253660 hasConceptScore W2441253660C2781300812 @default.
- W2441253660 hasConceptScore W2441253660C40465926 @default.
- W2441253660 hasConceptScore W2441253660C71924100 @default.
- W2441253660 hasConceptScore W2441253660C98274493 @default.
- W2441253660 hasIssue "4" @default.
- W2441253660 hasLocation W24412536601 @default.
- W2441253660 hasOpenAccess W2441253660 @default.
- W2441253660 hasPrimaryLocation W24412536601 @default.
- W2441253660 hasRelatedWork W160032309 @default.
- W2441253660 hasRelatedWork W1969630931 @default.
- W2441253660 hasRelatedWork W1971805906 @default.
- W2441253660 hasRelatedWork W2013488496 @default.
- W2441253660 hasRelatedWork W2013738267 @default.
- W2441253660 hasRelatedWork W2029665662 @default.
- W2441253660 hasRelatedWork W2268903811 @default.
- W2441253660 hasRelatedWork W2332004161 @default.
- W2441253660 hasRelatedWork W2406900103 @default.
- W2441253660 hasRelatedWork W2439619951 @default.
- W2441253660 hasVolume "37" @default.
- W2441253660 isParatext "false" @default.
- W2441253660 isRetracted "false" @default.
- W2441253660 magId "2441253660" @default.
- W2441253660 workType "article" @default.