FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2441297490> ?p ?o ?g. }

• W2441297490 endingPage "9" @default.
• W2441297490 startingPage "1" @default.
• W2441297490 abstract "Shikonin, an anti-inflammatory compound of Shikon, inhibits the neutrophil superoxide (O2 (•-)) generation by NADPH oxidase 2 (Nox2); however, the mechanisms of how shikonin affects Nox2 activity remained unclear. We aimed to elucidate the relationship between the inhibition of Nox2 activity and influences on intracellular Ca(2+) concentration ([Ca(2+)]i) by shikonin. For this purpose, we used a simultaneous monitoring system for detecting changes in [Ca(2+)]i (by fluorescence) and O2 (•-) generation (by chemiluminescence) and evaluated the effects of shikonin on neutrophil-like HL-60 cells stimulated with N-formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP). Since fMLP activates Nox2 by elevation in [Ca(2+)]i via fluxes such as inositol 1,4,5-trisphosphate-induced Ca(2+) release (IICR) and store-operated Ca(2+) entry (SOCE), we also evaluated the effects of shikonin on IICR and SOCE. Shikonin dose-dependently inhibited the fMLP-induced elevation in [Ca(2+)]i and O2 (•-) generation (IC50 values of 1.45 and 1.12 µM, respectively) in a synchronized manner. Analyses of specific Ca(2+) fluxes showed that shikonin inhibits IICR and IICR-linked O2 (•-) generation (IC50 values: 0.28 and 0.31 µM for [Ca(2+)]i and O2 (•-), respectively), as well as SOCE and SOCE-linked O2 (•-) generation (IC50 values: 0.39 and 0.25 µM for [Ca(2+)]i and O2 (•-), respectively). These results suggested that shikonin inhibits the O2 (•-) generation by Nox2 in fMLP-stimulated neutrophils by targeting Ca(2+) fluxes such as IICR and SOCE." @default.
• W2441297490 created "2016-06-24" @default.
• W2441297490 creator A5026554251 @default.
• W2441297490 creator A5057215954 @default.
• W2441297490 creator A5060687521 @default.
• W2441297490 creator A5062022557 @default.
• W2441297490 creator A5069387694 @default.
• W2441297490 creator A5075307523 @default.
• W2441297490 creator A5076608605 @default.
• W2441297490 creator A5078984314 @default.
• W2441297490 creator A5082873710 @default.
• W2441297490 date "2016-01-01" @default.
• W2441297490 modified "2023-10-14" @default.
• W2441297490 title "Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca²⁺ fluxes" @default.
• W2441297490 cites W1665071864 @default.
• W2441297490 cites W1910332340 @default.
• W2441297490 cites W1970754889 @default.
• W2441297490 cites W1972077069 @default.
• W2441297490 cites W1975232826 @default.
• W2441297490 cites W1976091625 @default.
• W2441297490 cites W1990074379 @default.
• W2441297490 cites W1998186108 @default.
• W2441297490 cites W1999709334 @default.
• W2441297490 cites W2000708353 @default.
• W2441297490 cites W2000754365 @default.
• W2441297490 cites W2001525535 @default.
• W2441297490 cites W2002061268 @default.
• W2441297490 cites W2013635636 @default.
• W2441297490 cites W2018538029 @default.
• W2441297490 cites W2019940225 @default.
• W2441297490 cites W2029310012 @default.
• W2441297490 cites W2030749341 @default.
• W2441297490 cites W2035715475 @default.
• W2441297490 cites W2036422868 @default.
• W2441297490 cites W2043380554 @default.
• W2441297490 cites W2050492563 @default.
• W2441297490 cites W2062450680 @default.
• W2441297490 cites W2063266096 @default.
• W2441297490 cites W2064816991 @default.
• W2441297490 cites W2065417669 @default.
• W2441297490 cites W2074777408 @default.
• W2441297490 cites W2076867308 @default.
• W2441297490 cites W2079931546 @default.
• W2441297490 cites W2080090883 @default.
• W2441297490 cites W2081346391 @default.
• W2441297490 cites W2090075893 @default.
• W2441297490 cites W2091150961 @default.
• W2441297490 cites W2091272795 @default.
• W2441297490 cites W2091352240 @default.
• W2441297490 cites W2095675672 @default.
• W2441297490 cites W2131815602 @default.
• W2441297490 cites W2132822330 @default.
• W2441297490 cites W2140976677 @default.
• W2441297490 cites W2144506280 @default.
• W2441297490 cites W2157378804 @default.
• W2441297490 cites W2169768846 @default.
• W2441297490 cites W2267790859 @default.
• W2441297490 cites W2396028691 @default.
• W2441297490 cites W2415911187 @default.
• W2441297490 cites W2005854744 @default.
• W2441297490 doi "https://doi.org/10.3164/jcbn.16-4" @default.
• W2441297490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4933695" @default.
• W2441297490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499572" @default.
• W2441297490 hasPublicationYear "2016" @default.
• W2441297490 type Work @default.
• W2441297490 sameAs 2441297490 @default.
• W2441297490 citedByCount "7" @default.
• W2441297490 countsByYear W24412974902017 @default.
• W2441297490 countsByYear W24412974902018 @default.
• W2441297490 countsByYear W24412974902019 @default.
• W2441297490 countsByYear W24412974902021 @default.
• W2441297490 countsByYear W24412974902022 @default.
• W2441297490 crossrefType "journal-article" @default.
• W2441297490 hasAuthorship W2441297490A5026554251 @default.
• W2441297490 hasAuthorship W2441297490A5057215954 @default.
• W2441297490 hasAuthorship W2441297490A5060687521 @default.
• W2441297490 hasAuthorship W2441297490A5062022557 @default.
• W2441297490 hasAuthorship W2441297490A5069387694 @default.
• W2441297490 hasAuthorship W2441297490A5075307523 @default.
• W2441297490 hasAuthorship W2441297490A5076608605 @default.
• W2441297490 hasAuthorship W2441297490A5078984314 @default.
• W2441297490 hasAuthorship W2441297490A5082873710 @default.
• W2441297490 hasBestOaLocation W24412974901 @default.
• W2441297490 hasConcept C145802702 @default.
• W2441297490 hasConcept C153911025 @default.
• W2441297490 hasConcept C170493617 @default.
• W2441297490 hasConcept C178790620 @default.
• W2441297490 hasConcept C181199279 @default.
• W2441297490 hasConcept C185592680 @default.
• W2441297490 hasConcept C198677920 @default.
• W2441297490 hasConcept C202751555 @default.
• W2441297490 hasConcept C2777427919 @default.
• W2441297490 hasConcept C2779719074 @default.
• W2441297490 hasConcept C2780795997 @default.
• W2441297490 hasConcept C48349386 @default.
• W2441297490 hasConcept C55493867 @default.
• W2441297490 hasConcept C79879829 @default.
• W2441297490 hasConcept C86803240 @default.

• next