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• W2441772251 abstract "Objective: Several observational studies have shown that metformin therapy may modify the risk of pros- tate cancer. We carried out a meta-analysis of relevant studies evaluating the effect of metformin therapy on pros- tate cancer risk. Methods: We searched pubmed database (January 1966-February 2014) for case-control and cohort studies that assessed metformin therapy and prostate cancer risk. Two authors independently assessed eligibility and extracted data. Summary RRs was calculated using fixed-effects model or random-effects model. Heterogeneity among studies was examined using Q and I 2 statistics. Results: We included six cohort studies and four case-control studies in the present meta-analysis, comprising 863,769 participants and 39,073 prostate can- cer cases. The pooled RR of prostate cancer in relation to metformin therapy was 0.92 (95% CI: 0.84-1.02, P = 0.112). When we stratified the various studies by study type, we found that metformin therapy was associated with a significant reduced risk of prostate cancer among cohort studies (RR = 0.92, 95% CI (0.87, 0.96), P<0.001); however, no significant association was detected among case-control studies (RR = 0.95, 95% CI (0.78, 1.16), P = 0.632). There was also no indication of publication bias as suggested by Begg's test (P = 0.421) and Egger's test (P = 0.627). Conclusion: Our findings indicate that metformin therapy is not significantly associated with lower prostate cancer risk." @default.
• W2441772251 created "2016-06-24" @default.
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• W2441772251 date "2015-01-01" @default.
• W2441772251 modified "2023-09-26" @default.
• W2441772251 title "Original Article Metformin therapy and prostate cancer risk: a meta-analysis of observational studies" @default.
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• W2441772251 hasPublicationYear "2015" @default.
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