Matches in SemOpenAlex for { <https://semopenalex.org/work/W2441796404> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2441796404 endingPage "680" @default.
- W2441796404 startingPage "676" @default.
- W2441796404 abstract "Methotrexate (MTX) is an anticancer drug. Many studies have reported that MTX causes oxidative stress-associated damage in the small intestine. The purpose of this study was to investigate the possible protective effect of resveratrol (RES), an antioxidant, against MTX-induced damage in the small intestine.Twenty-four Spraque Dawley rats were randomly divided into four groups; the control group, the RES group given 20 mg/kg RES for 10 days, the MTX group given single dose 30 mg/kg MTX, MTX+RES group given 20 mg/kg RES i.p. for 7 days and 30 mg/ kg MTX i.p. on the 7th day, RES being maintained for 3 further days. All rats were sacrificed on the 10th day, and small intestinal tissue was removed for histopathological and biochemical analysis. Additionally, mucosal apoptosis was analyzed using the TUNEL method.Histopathologically, villar fusion, atrophic villus epithelium, cystic expansion in crypts, hemorrhage and inflammatory cell infiltration were seen in the small intestine in the MTX group. In the MTX+RES group this histopathological damage decreased significantly. Apoptotic score was significantly higher in the MTX group and significantly lower in the MTX+RES group. Tissue malondialdehyde (MDA) level was significantly higher in the MTX group. Superoxide dismutase (SOD) activity was significantly decreased in the MTX group. The MDA level in the MTX+RES group decreased while SOD and catalase (CAT) activities rose, this was not statistically significant." @default.
- W2441796404 created "2016-06-24" @default.
- W2441796404 creator A5002408206 @default.
- W2441796404 creator A5035934372 @default.
- W2441796404 creator A5044818353 @default.
- W2441796404 creator A5075460917 @default.
- W2441796404 date "2015-01-01" @default.
- W2441796404 modified "2023-10-10" @default.
- W2441796404 title "Effects of resveratrol on methotrexate-induced intestinal injury" @default.
- W2441796404 doi "https://doi.org/10.4149/bll_2015_132" @default.
- W2441796404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26621167" @default.
- W2441796404 hasPublicationYear "2015" @default.
- W2441796404 type Work @default.
- W2441796404 sameAs 2441796404 @default.
- W2441796404 citedByCount "4" @default.
- W2441796404 countsByYear W24417964042022 @default.
- W2441796404 countsByYear W24417964042023 @default.
- W2441796404 crossrefType "journal-article" @default.
- W2441796404 hasAuthorship W2441796404A5002408206 @default.
- W2441796404 hasAuthorship W2441796404A5035934372 @default.
- W2441796404 hasAuthorship W2441796404A5044818353 @default.
- W2441796404 hasAuthorship W2441796404A5075460917 @default.
- W2441796404 hasBestOaLocation W24417964041 @default.
- W2441796404 hasConcept C121332964 @default.
- W2441796404 hasConcept C126322002 @default.
- W2441796404 hasConcept C153400128 @default.
- W2441796404 hasConcept C16685009 @default.
- W2441796404 hasConcept C185592680 @default.
- W2441796404 hasConcept C190283241 @default.
- W2441796404 hasConcept C196795494 @default.
- W2441796404 hasConcept C2775838275 @default.
- W2441796404 hasConcept C2776151105 @default.
- W2441796404 hasConcept C2776816829 @default.
- W2441796404 hasConcept C2777882243 @default.
- W2441796404 hasConcept C2778401633 @default.
- W2441796404 hasConcept C2778979269 @default.
- W2441796404 hasConcept C2780829032 @default.
- W2441796404 hasConcept C2781059491 @default.
- W2441796404 hasConcept C55493867 @default.
- W2441796404 hasConcept C71924100 @default.
- W2441796404 hasConcept C97355855 @default.
- W2441796404 hasConcept C98274493 @default.
- W2441796404 hasConceptScore W2441796404C121332964 @default.
- W2441796404 hasConceptScore W2441796404C126322002 @default.
- W2441796404 hasConceptScore W2441796404C153400128 @default.
- W2441796404 hasConceptScore W2441796404C16685009 @default.
- W2441796404 hasConceptScore W2441796404C185592680 @default.
- W2441796404 hasConceptScore W2441796404C190283241 @default.
- W2441796404 hasConceptScore W2441796404C196795494 @default.
- W2441796404 hasConceptScore W2441796404C2775838275 @default.
- W2441796404 hasConceptScore W2441796404C2776151105 @default.
- W2441796404 hasConceptScore W2441796404C2776816829 @default.
- W2441796404 hasConceptScore W2441796404C2777882243 @default.
- W2441796404 hasConceptScore W2441796404C2778401633 @default.
- W2441796404 hasConceptScore W2441796404C2778979269 @default.
- W2441796404 hasConceptScore W2441796404C2780829032 @default.
- W2441796404 hasConceptScore W2441796404C2781059491 @default.
- W2441796404 hasConceptScore W2441796404C55493867 @default.
- W2441796404 hasConceptScore W2441796404C71924100 @default.
- W2441796404 hasConceptScore W2441796404C97355855 @default.
- W2441796404 hasConceptScore W2441796404C98274493 @default.
- W2441796404 hasIssue "11" @default.
- W2441796404 hasLocation W24417964041 @default.
- W2441796404 hasLocation W24417964042 @default.
- W2441796404 hasOpenAccess W2441796404 @default.
- W2441796404 hasPrimaryLocation W24417964041 @default.
- W2441796404 hasRelatedWork W2040712997 @default.
- W2441796404 hasRelatedWork W2041257525 @default.
- W2441796404 hasRelatedWork W2066642331 @default.
- W2441796404 hasRelatedWork W2158849542 @default.
- W2441796404 hasRelatedWork W2183540883 @default.
- W2441796404 hasRelatedWork W2441796404 @default.
- W2441796404 hasRelatedWork W2889329188 @default.
- W2441796404 hasRelatedWork W2958374161 @default.
- W2441796404 hasRelatedWork W4285037963 @default.
- W2441796404 hasRelatedWork W4313039917 @default.
- W2441796404 hasVolume "116" @default.
- W2441796404 isParatext "false" @default.
- W2441796404 isRetracted "false" @default.
- W2441796404 magId "2441796404" @default.
- W2441796404 workType "article" @default.