FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2442313538> ?p ?o ?g. }

• W2442313538 endingPage "341" @default.
• W2442313538 startingPage "331" @default.
• W2442313538 abstract "SummaryRat liver mitochondria have a specific Ca2+ release pathway which operates when NAD+ is hydrolysed to nicotinamide and ADPribose. NAD+ hydrolysis is Ca2+-dependent and inhibited by cyclosporine A (CSA). Mitochondrial Ca2+ release can be activated by the prooxidant t-butylhydroperoxide (tbh) or by gliotoxin (GT), a fungal metabolite of the epipolythiodioxopiperazine group. Tbh oxidizes NADH to NAD+ through an enzyme cascade consisting of glutathione peroxidase, glutathione reductase, and the energy linked transhydrogenase, whereas GT oxidizes some vicinal thiols to the disulfide form, a prerequisite for NAD+ hydrolysis. We report now that rat skeletal muscle mitochondria also contain a specific Ca2+ release pathway activated by both tbh and GT. Ca2+ release increases with the mitochondrial Ca2+ load, is completely inhibited in the presence of CSA, and is paralleled by pyridine nucleotide oxidation. In the presence of tbh and GT, mitochondria do not lose their membrane potential and do not swell, provided continuous release and re-uptake of Ca2+ (‘Ca2+ cycling’) is prevented. These data support the notion that both tbh- and GT-induced Ca2+ release are not the consequence of an unspecific increase of the inner membrane permeability (‘pore’ formation). Tbh induces Ca2+ release from rat skeletal muscle less efficiently than from liver mitochondria indicating that the coupling between tbh and NADH oxidation is much weaker in skeletal muscle mitochondria. This conclusion is corroborated by a much lower glutathione peroxidase activity in skeletal muscle than in liver mitochondria. The prooxidant-dependent pathway promotes, under drastic conditions (high mitochondrial Ca2+ loads and high tbh concentrations), Ca2+ release to about the same extent and rate as the Na+/Ca2+ exchanger. This renders the prooxidant-dependent pathway relevant in the pathophysiology of mitochondrial myopathies where its activation by an increased generation of reactive oxygen species probably results in excessive Ca2+ cycling and damage to mitochondria." @default.
• W2442313538 created "2016-06-24" @default.
• W2442313538 creator A5022202339 @default.
• W2442313538 creator A5036794157 @default.
• W2442313538 creator A5044379358 @default.
• W2442313538 date "1997-10-01" @default.
• W2442313538 modified "2023-10-10" @default.
• W2442313538 title "<i>t</i>-Butylhydroperoxide and gliotoxin stimulate Ca²⁺release from rat skeletal muscle mitochondria" @default.
• W2442313538 cites W1492823505 @default.
• W2442313538 cites W1506478670 @default.
• W2442313538 cites W1533515471 @default.
• W2442313538 cites W1555283812 @default.
• W2442313538 cites W1557154662 @default.
• W2442313538 cites W1559795048 @default.
• W2442313538 cites W164548000 @default.
• W2442313538 cites W1767614014 @default.
• W2442313538 cites W1967268953 @default.
• W2442313538 cites W1970881583 @default.
• W2442313538 cites W1971804221 @default.
• W2442313538 cites W1975551314 @default.
• W2442313538 cites W2027608784 @default.
• W2442313538 cites W2057519741 @default.
• W2442313538 cites W2073706613 @default.
• W2442313538 cites W2084665287 @default.
• W2442313538 cites W2090233706 @default.
• W2442313538 cites W2094821743 @default.
• W2442313538 cites W2094901741 @default.
• W2442313538 cites W2150200455 @default.
• W2442313538 cites W2150529798 @default.
• W2442313538 cites W2176061808 @default.
• W2442313538 cites W2241448607 @default.
• W2442313538 cites W2409468262 @default.
• W2442313538 cites W2470674650 @default.
• W2442313538 doi "https://doi.org/10.1080/13510002.1997.11747131" @default.
• W2442313538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9754333" @default.
• W2442313538 hasPublicationYear "1997" @default.
• W2442313538 type Work @default.
• W2442313538 sameAs 2442313538 @default.
• W2442313538 citedByCount "8" @default.
• W2442313538 countsByYear W24423135382015 @default.
• W2442313538 crossrefType "journal-article" @default.
• W2442313538 hasAuthorship W2442313538A5022202339 @default.
• W2442313538 hasAuthorship W2442313538A5036794157 @default.
• W2442313538 hasAuthorship W2442313538A5044379358 @default.
• W2442313538 hasBestOaLocation W24423135381 @default.
• W2442313538 hasConcept C134018914 @default.
• W2442313538 hasConcept C181199279 @default.
• W2442313538 hasConcept C185592680 @default.
• W2442313538 hasConcept C2778760513 @default.
• W2442313538 hasConcept C2779728014 @default.
• W2442313538 hasConcept C2779959927 @default.
• W2442313538 hasConcept C28859421 @default.
• W2442313538 hasConcept C538909803 @default.
• W2442313538 hasConcept C55493867 @default.
• W2442313538 hasConcept C75520062 @default.
• W2442313538 hasConcept C86803240 @default.
• W2442313538 hasConceptScore W2442313538C134018914 @default.
• W2442313538 hasConceptScore W2442313538C181199279 @default.
• W2442313538 hasConceptScore W2442313538C185592680 @default.
• W2442313538 hasConceptScore W2442313538C2778760513 @default.
• W2442313538 hasConceptScore W2442313538C2779728014 @default.
• W2442313538 hasConceptScore W2442313538C2779959927 @default.
• W2442313538 hasConceptScore W2442313538C28859421 @default.
• W2442313538 hasConceptScore W2442313538C538909803 @default.
• W2442313538 hasConceptScore W2442313538C55493867 @default.
• W2442313538 hasConceptScore W2442313538C75520062 @default.
• W2442313538 hasConceptScore W2442313538C86803240 @default.
• W2442313538 hasIssue "5-6" @default.
• W2442313538 hasLocation W24423135381 @default.
• W2442313538 hasLocation W24423135382 @default.
• W2442313538 hasOpenAccess W2442313538 @default.
• W2442313538 hasPrimaryLocation W24423135381 @default.
• W2442313538 hasRelatedWork W1974485322 @default.
• W2442313538 hasRelatedWork W1979784914 @default.
• W2442313538 hasRelatedWork W2013605216 @default.
• W2442313538 hasRelatedWork W2029948715 @default.
• W2442313538 hasRelatedWork W2037110795 @default.
• W2442313538 hasRelatedWork W2315088565 @default.
• W2442313538 hasRelatedWork W2361358236 @default.
• W2442313538 hasRelatedWork W2405176976 @default.
• W2442313538 hasRelatedWork W4289955449 @default.
• W2442313538 hasRelatedWork W4290012698 @default.
• W2442313538 hasVolume "3" @default.
• W2442313538 isParatext "false" @default.
• W2442313538 isRetracted "false" @default.
• W2442313538 magId "2442313538" @default.
• W2442313538 workType "article" @default.