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- W2442425797 abstract "Although previous studies suggest that proplatelet formation in megakaryocytes involves caspase-3, the mechanism underlying the activation of caspase-3 is unknown. Here, we analyzed caspase activation in a human megakaryoblastic cell line, MEG-01, which forms proplatelets spontaneously. Specific activation of caspase-3 and caspase-4 was found in proplatelets. Consistent with previous observations of caspase-4 autoactivation in response to endoplasmic reticulum (ER) stress, several ER stress marker proteins were expressed during proplatelet formation. A pharmacological ER stressor enhanced platelet production via proplatelet formation, whereas inhibition of caspase-4 caused suppression. These results suggest that ER stress is a mechanism underlying the maturation of megakaryocytes." @default.
- W2442425797 created "2016-06-24" @default.
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- W2442425797 date "2016-06-14" @default.
- W2442425797 modified "2023-10-05" @default.
- W2442425797 title "Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress" @default.
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- W2442425797 doi "https://doi.org/10.1111/gtc.12384" @default.
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