Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443001171> ?p ?o ?g. }
- W2443001171 abstract "Peritoneal macrophages are one of the most studied macrophage populations in the body, yet the composition, developmental origin and mechanisms governing the maintenance of this compartment are controversial. Here we show resident F4/80(hi)GATA6(+) macrophages are long-lived, undergo non-stochastic self-renewal and retain cells of embryonic origin for at least 4 months in mice. However, Ly6C(+) monocytes constitutively enter the peritoneal cavity in a CCR2-dependent manner, where they mature into short-lived F4/80(lo)MHCII(+) cells that act, in part, as precursors of F4/80(hi)GATA6(+) macrophages. Notably, monocyte-derived F4/80(hi) macrophages eventually displace the embryonic population with age in a process that is highly gender dependent and not due to proliferative exhaustion of the incumbent embryonic population, despite the greater proliferative activity of newly recruited cells. Furthermore, although monocyte-derived cells acquire key characteristics of the embryonic population, expression of Tim4 was impaired, leading to cumulative changes in the population with age." @default.
- W2443001171 created "2016-06-24" @default.
- W2443001171 creator A5002734104 @default.
- W2443001171 creator A5003549501 @default.
- W2443001171 creator A5016619631 @default.
- W2443001171 creator A5017955309 @default.
- W2443001171 creator A5020862678 @default.
- W2443001171 creator A5028015444 @default.
- W2443001171 creator A5063357947 @default.
- W2443001171 creator A5076127036 @default.
- W2443001171 creator A5077216157 @default.
- W2443001171 creator A5085234051 @default.
- W2443001171 creator A5085709802 @default.
- W2443001171 creator A5086634395 @default.
- W2443001171 date "2016-06-13" @default.
- W2443001171 modified "2023-10-11" @default.
- W2443001171 title "Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities" @default.
- W2443001171 cites W1528449305 @default.
- W2443001171 cites W1573789548 @default.
- W2443001171 cites W1934989380 @default.
- W2443001171 cites W1948478725 @default.
- W2443001171 cites W1964378492 @default.
- W2443001171 cites W1968034850 @default.
- W2443001171 cites W1973433801 @default.
- W2443001171 cites W1977536320 @default.
- W2443001171 cites W1984574450 @default.
- W2443001171 cites W1993603859 @default.
- W2443001171 cites W1995299599 @default.
- W2443001171 cites W1997349847 @default.
- W2443001171 cites W1999788583 @default.
- W2443001171 cites W2001344153 @default.
- W2443001171 cites W2010484682 @default.
- W2443001171 cites W2010876644 @default.
- W2443001171 cites W2014035331 @default.
- W2443001171 cites W2022485121 @default.
- W2443001171 cites W2023666964 @default.
- W2443001171 cites W2025349474 @default.
- W2443001171 cites W2044224359 @default.
- W2443001171 cites W2046737138 @default.
- W2443001171 cites W2047449373 @default.
- W2443001171 cites W2055724614 @default.
- W2443001171 cites W2068714945 @default.
- W2443001171 cites W2069891658 @default.
- W2443001171 cites W2072149273 @default.
- W2443001171 cites W2076086749 @default.
- W2443001171 cites W2091487793 @default.
- W2443001171 cites W2098954540 @default.
- W2443001171 cites W2100067750 @default.
- W2443001171 cites W2100646399 @default.
- W2443001171 cites W2102100445 @default.
- W2443001171 cites W2103153413 @default.
- W2443001171 cites W2104299175 @default.
- W2443001171 cites W2104431737 @default.
- W2443001171 cites W2106329796 @default.
- W2443001171 cites W2109484392 @default.
- W2443001171 cites W2114675972 @default.
- W2443001171 cites W2116634113 @default.
- W2443001171 cites W2118363577 @default.
- W2443001171 cites W2121780600 @default.
- W2443001171 cites W2126811287 @default.
- W2443001171 cites W2130745198 @default.
- W2443001171 cites W2131746171 @default.
- W2443001171 cites W2133019048 @default.
- W2443001171 cites W2133793569 @default.
- W2443001171 cites W2135703618 @default.
- W2443001171 cites W2136188258 @default.
- W2443001171 cites W2138780833 @default.
- W2443001171 cites W2142242761 @default.
- W2443001171 cites W2142415307 @default.
- W2443001171 cites W2143333572 @default.
- W2443001171 cites W2153406260 @default.
- W2443001171 cites W2153846543 @default.
- W2443001171 cites W2153960708 @default.
- W2443001171 cites W2156236394 @default.
- W2443001171 cites W2156261200 @default.
- W2443001171 cites W2163774748 @default.
- W2443001171 cites W2166791153 @default.
- W2443001171 cites W2170625377 @default.
- W2443001171 cites W2170851221 @default.
- W2443001171 cites W2206527692 @default.
- W2443001171 cites W2220698190 @default.
- W2443001171 cites W2242760558 @default.
- W2443001171 cites W2268619028 @default.
- W2443001171 cites W2343063221 @default.
- W2443001171 cites W78744612 @default.
- W2443001171 doi "https://doi.org/10.1038/ncomms11852" @default.
- W2443001171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4910019" @default.
- W2443001171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27292029" @default.
- W2443001171 hasPublicationYear "2016" @default.
- W2443001171 type Work @default.
- W2443001171 sameAs 2443001171 @default.
- W2443001171 citedByCount "253" @default.
- W2443001171 countsByYear W24430011712016 @default.
- W2443001171 countsByYear W24430011712017 @default.
- W2443001171 countsByYear W24430011712018 @default.
- W2443001171 countsByYear W24430011712019 @default.
- W2443001171 countsByYear W24430011712020 @default.
- W2443001171 countsByYear W24430011712021 @default.
- W2443001171 countsByYear W24430011712022 @default.
- W2443001171 countsByYear W24430011712023 @default.