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• W2443138977 startingPage "1631" @default.
• W2443138977 abstract "D'Angelo, Egidio, Giovanna De Filippi, Paola Rossi, and Vanni Taglietti. Synaptic activation of Ca 2+ action potentials in immature rat cerebellar granule cells in situ. J. Neurophysiol. 78: 1631–1642, 1997. Although numerous Ca 2+ channels have been identified in cerebellar granule cells, their role in regulating excitability remained unclear. We therefore investigated the excitable response in granule cells using whole cell patch-clamp recordings in acute rat cerebellar slices throughout the time of development (P4–P21, n = 183), with the aim of identifying the role of Ca 2+ channels and their activation mechanism. After depolarizing current injection, 46% of granule cells showed Ca 2+ action potentials, whereas repetitive Na + spikes were observed in an increasing proportion of granule cells from P4 to P21. Because Ca 2+ action potentials were no longer observed after P21, they characterized an immature granule cell functional stage. Ca 2+ action potentials consisted of an intermediate-threshold spike (ITS) activating at −60/−50 mV and sensitive to voltage inactivation and of a high-threshold spike (HTS), activating at above −30 mV and resistant to voltage inactivation. Both ITS and HTS comprised transient and protracted Ca 2+ channel-dependent depolarizations. The Ca 2+ action potentials could be activated synaptically by excitatory postsynaptic potentials, which were significantly slower and had a proportionately greater N-methyl-d-aspartate (NMDA) receptor-mediated component than those recorded in cells with fast repetitive Na + spikes. The NMDA receptor current, by providing a sustained and regenerative current injection, was critical for activating the ITS, which was not self-regenerative. Moreover, NMDA receptors determined temporal summation of impulses during repetitive mossy fiber transmission, raising membrane potential into the range required for generating protracted Ca 2+ channel-dependent depolarizations. The nature of Ca 2+ action potentials was considered further using selective ion channel blockers. N-, L-, and P-type Ca 2+ channels generated protracted depolarizations, whereas the ITS and HTS transient phase was generated by putative R-type channels (R ITS and R HTS , respectively). R HTS channels had a higher activation threshold and were more resistant to voltage inactivation than R ITS channels. At a mature stage, most of the Ca 2+ -dependent effects depended on the N-type current, which promoted spike repolarization and regulated the Na + -dependent discharge frequency. These observations relate Ca 2+ channel types with specific neuronal excitable properties and developmental states in situ. Synaptic NMDA receptor-dependent activation of Ca 2+ action potentials provides a sophisticated mechanism for Ca 2+ signaling, which might be involved in granule cell development and plasticity." @default.
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• W2443138977 date "1997-09-01" @default.
• W2443138977 modified "2023-10-12" @default.
• W2443138977 title "Synaptic Activation of Ca²⁺ Action Potentials in Immature Rat Cerebellar Granule Cells In Situ" @default.
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• W2443138977 doi "https://doi.org/10.1152/jn.1997.78.3.1631" @default.
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