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- W2443281924 abstract "A study was made of the intrathecal infusion as a route of administration of drugs for the CNS, by giving due consideration to the presence of blood-brain and CSF-brain barriers. CDP-choline was used as the brain activator, and the effect of the drug intrathecally infused was investigated both clinically and by experiments on animals. Seven patients with a disturbance of consciousness due to primary brain lesion received a total of 19 intrathecal infusions of CDP-choline, and were examined for the effect of the treatment neurologically and electroencephalographically. Wistar rats were infused either intravascularly or intracisternally with 14C-CDP-choline, and the distribution in the body was investigated by whole body autoradiography." @default.
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- W2443281924 date "1975-10-01" @default.
- W2443281924 modified "2023-09-26" @default.
- W2443281924 title "Studies on the intrathecal pharmacotherapy. Part I: CDP-choline." @default.
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