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- W2443282088 abstract "andradioimmunoassay with negative results. Eluates ofsynovial membrane prepared under conditions likely todissociate antigen-antibody complexes haveshownno rubella antibody. A serological surveyofRA patients andthose withother forms ofarthritis hasshownno differences inthefrequency or levels ofrubella haemagglutination-inhibiting antibody. These results provide little supportforvarious hypotheses that a persistent infection withrubella virus underlies orinitiates therheumatoid process. The phenomenon of persistent infection with rubella virus isfamiliar fromthecongenital rubella syndrome andfromsomepatients withavariety of subacute sclerosing panencephalitis (Townsend etal., 1975; Weiletal., 1975), andalso frompersistent infection ofcultured cells invitro. Thetendency, taken with theobservation ofaself-limiting synovitis asanoccasional complication ofacute rubella, lends attraction toahypothesis that apersistent infection ofsynovial cells withrubella virus mightbethe ultimate antigenic stimulus injuvenile (JRA)or adult rheumatoid arthritis (RA). To testthishypothesis numerousworkers havecompared thefrequency, ormeantitre, of rubella antibody inrheumatoid patients withthat incontrol groups ofhealthy persons, orpatients suffering fromother formsofarthritis (Chandler etal., 1971; Laitinen etal., 1972; Simsarian etal., 1970; Deinard etal., 1974). These studies havegenerally failed toshowa difference except forthose described byPatterson etal., (1973 andpersonal communication) andDeinard etal.(1974). Other workers haveexamined antibody fromRA synovial fluid cryoprecipitates, oreluates fromRA synovial" @default.
- W2443282088 created "2016-06-24" @default.
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- W2443282088 date "1977-01-01" @default.
- W2443282088 modified "2023-09-26" @default.
- W2443282088 title "Rubella virus andrheumatoid arthritis" @default.
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