Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443283797> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2443283797 endingPage "32" @default.
- W2443283797 startingPage "823" @default.
- W2443283797 abstract "Pyrethroid insecticides bind to a unique site on voltage-dependent sodium channels and prolong sodium currents, leading to repetitive bursts of action potentials or use-dependent nerve block. To further characterize the site and mode of action of pyrethroids on sodium channels, we injected synthetic mRNA encoding the rat brain IIa sodium channel alpha subunit, either alone or in combination with synthetic mRNA encoding the rat sodium channel beta1 subunit, into oocytes of the frog Xenopus laevis and assessed the actions of the pyrethroid insecticide [1R,cis,alphaS]-cypermethrin on expressed sodium currents by two-electrode voltage clamp. In oocytes expressing only the rat brain IIa alpha subunit, cypermethrin produced a slowly-decaying sodium tail current following a depolarizing pulse. In parallel experiments using oocytes expressing the rat brain IIa alpha subunit in combination with the rat beta1 subunit, cypermethrin produced qualitatively similar tail currents following a depolarizing pulse and also induced a sustained component of the sodium current measured during a step depolarization of the oocyte membrane. The voltage dependence of activation and steady-state inactivation of the cypermethrin-dependent sustained current were identical to those of the peak transient sodium current measured in the absence of cypermethrin. Concentration-response curves obtained using normalized tail current amplitude as an index of the extent of sodium channel modification by cypermethrin revealed that coexpression of the rat brain IIa alpha subunit with the rat beta1 subunit increased the apparent affinity of the sodium channel binding site for cypermethrin by more than 20-fold. These results confirm that the pyrethroid binding site is intrinsic to the sodium channel alpha subunit and demonstrate that coexpression of the rat brain IIa alpha subunit with the rat beta1 subunit alters the apparent affinity of this site for pyrethroids." @default.
- W2443283797 created "2016-06-24" @default.
- W2443283797 creator A5029393649 @default.
- W2443283797 creator A5079130653 @default.
- W2443283797 date "1998-12-01" @default.
- W2443283797 modified "2023-10-05" @default.
- W2443283797 title "Action of the pyrethroid insecticide cypermethrin on rat brain IIa sodium channels expressed in xenopus oocytes." @default.
- W2443283797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9863771" @default.
- W2443283797 hasPublicationYear "1998" @default.
- W2443283797 type Work @default.
- W2443283797 sameAs 2443283797 @default.
- W2443283797 citedByCount "21" @default.
- W2443283797 countsByYear W24432837972012 @default.
- W2443283797 countsByYear W24432837972014 @default.
- W2443283797 countsByYear W24432837972016 @default.
- W2443283797 countsByYear W24432837972017 @default.
- W2443283797 countsByYear W24432837972018 @default.
- W2443283797 crossrefType "journal-article" @default.
- W2443283797 hasAuthorship W2443283797A5029393649 @default.
- W2443283797 hasAuthorship W2443283797A5079130653 @default.
- W2443283797 hasConcept C100837961 @default.
- W2443283797 hasConcept C104292427 @default.
- W2443283797 hasConcept C104317684 @default.
- W2443283797 hasConcept C12554922 @default.
- W2443283797 hasConcept C161176658 @default.
- W2443283797 hasConcept C178790620 @default.
- W2443283797 hasConcept C181911157 @default.
- W2443283797 hasConcept C185592680 @default.
- W2443283797 hasConcept C2776035571 @default.
- W2443283797 hasConcept C2779437720 @default.
- W2443283797 hasConcept C2779535977 @default.
- W2443283797 hasConcept C4141045 @default.
- W2443283797 hasConcept C50952357 @default.
- W2443283797 hasConcept C537181965 @default.
- W2443283797 hasConcept C55493867 @default.
- W2443283797 hasConcept C6557445 @default.
- W2443283797 hasConcept C83730767 @default.
- W2443283797 hasConcept C86803240 @default.
- W2443283797 hasConcept C98274493 @default.
- W2443283797 hasConceptScore W2443283797C100837961 @default.
- W2443283797 hasConceptScore W2443283797C104292427 @default.
- W2443283797 hasConceptScore W2443283797C104317684 @default.
- W2443283797 hasConceptScore W2443283797C12554922 @default.
- W2443283797 hasConceptScore W2443283797C161176658 @default.
- W2443283797 hasConceptScore W2443283797C178790620 @default.
- W2443283797 hasConceptScore W2443283797C181911157 @default.
- W2443283797 hasConceptScore W2443283797C185592680 @default.
- W2443283797 hasConceptScore W2443283797C2776035571 @default.
- W2443283797 hasConceptScore W2443283797C2779437720 @default.
- W2443283797 hasConceptScore W2443283797C2779535977 @default.
- W2443283797 hasConceptScore W2443283797C4141045 @default.
- W2443283797 hasConceptScore W2443283797C50952357 @default.
- W2443283797 hasConceptScore W2443283797C537181965 @default.
- W2443283797 hasConceptScore W2443283797C55493867 @default.
- W2443283797 hasConceptScore W2443283797C6557445 @default.
- W2443283797 hasConceptScore W2443283797C83730767 @default.
- W2443283797 hasConceptScore W2443283797C86803240 @default.
- W2443283797 hasConceptScore W2443283797C98274493 @default.
- W2443283797 hasIssue "6" @default.
- W2443283797 hasLocation W24432837971 @default.
- W2443283797 hasOpenAccess W2443283797 @default.
- W2443283797 hasPrimaryLocation W24432837971 @default.
- W2443283797 hasRelatedWork W1984877619 @default.
- W2443283797 hasRelatedWork W2018589585 @default.
- W2443283797 hasRelatedWork W2027695518 @default.
- W2443283797 hasRelatedWork W2030910149 @default.
- W2443283797 hasRelatedWork W2032623633 @default.
- W2443283797 hasRelatedWork W2059081000 @default.
- W2443283797 hasRelatedWork W2075037235 @default.
- W2443283797 hasRelatedWork W2076000844 @default.
- W2443283797 hasRelatedWork W2125080283 @default.
- W2443283797 hasRelatedWork W2443283797 @default.
- W2443283797 hasVolume "19" @default.
- W2443283797 isParatext "false" @default.
- W2443283797 isRetracted "false" @default.
- W2443283797 magId "2443283797" @default.
- W2443283797 workType "article" @default.