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- W244353090 abstract "Aims: Low rectal cancer treated with abdomino-perineal resection (APR) compared with anterior resection has been shown to have higher rates of local recurrence (LR). It is thought that changes in surgical technique can improve outcomes and increasingly radical operations for tumours not amenable to restoration of bowel continuity are now being practiced. We investigated factors influencing recurrence in patients undergoing APR in our institution. Methods: Consecutive patients who underwent APR for rectal adenocarcinoma between August 2000 and August 2005 in a large single centre were retrospectively analysed, with a minimum follow up of 60 months. Results: 68 patients underwent APR, mean age was 65 years. Pre-operative radiotherapy was given in 29 (43%) patients. There was 2.9% in-hospital mortality (n=2). 20.6% (n=14) had a circumferential resection margin (CRM) ?1mm. There were 4 intra-operative rectal perforations (5.9%). Overall there was a 7.3% LR rate (n=5). There was 1.9% LR amongst the CRM -ve group (1/54) and 28.6% LR amongst the CRM +ve group (4/14). Conclusions: Our historical results for operative outcomes using conventional APR do not replicate the very high rates of incomplete resection and intra-operative tumour perforation that have been described in some reports. Our series demonstrates a link between circumferential resection margin positivity and local recurrence particularly in advanced tumours. Radiotherapy may not prevent local recurrence in those who have sub-optimal surgery." @default.
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- W244353090 date "2014-01-01" @default.
- W244353090 modified "2023-09-27" @default.
- W244353090 title "Operative and Survival Outcomes with Selective Neo-adjuvant Radiotherapy and Conventional Abdomino-Perineal Resection" @default.
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