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- W244355320 abstract "As part of our recent study on mitochondria injury and increased apoptosis in lymphocyte spleen cells of young chickens fed high fluoride (F) diets containing 400, 800, and 1200 mg F/kg, the spleen growth indexes in the two high F groups II and III were found to be markedly lower than in the control group. Histopathologically, in these two high F groups the number of splenic nodules and the lymphocyte population with splenic nodules and periarterial lymphatic sheaths in white pulp were obviously decreased along with the widened splenic sinus and erratically arranged lymphocytes in red pulp. Moreover, lymphocytes in G0/G1 phase were significantly increased, whereas lymphocytes in S phase and G2+M phase and the proliferation index (PI) were markedly decreased in the high F groups II and III. The results confirmed that high dietary F in the range of 800~1200 mg/kg inhibited the proliferation of splenocytes and suppressed spleen development in young chickens." @default.
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- W244355320 date "2009-01-01" @default.
- W244355320 modified "2023-09-29" @default.
- W244355320 title "Inhibition of splenocyte proliferation and spleen growth in young chickens fed high fluoride diets." @default.
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