Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443669561> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2443669561 endingPage "446" @default.
- W2443669561 startingPage "437" @default.
- W2443669561 abstract "Summary A synthetic iodopeptide having a glutamic acid-diiodotyrosine molar ratio of 1:1 has been shown to be an effective anticoagulant both in vivo and in vitro. Contrasted with heparin the following general conclusions may be made regarding its action. The iodopeptide does not act through the inactivation of thrombin in plasma. Iodopeptide does interact with fibrinogen to form a complex which, in vitro, is not soluble in buffered saline at physiological pH. At pH 8, iodopeptide interacts with fibrinogen to form a soluble complex in the presence of 0.9 % NaCl that is not coaguable either by thrombin or Crotalus venom enzymes. All the available evidence indicates that the fibrinogen to fibrin conversion is not inhibited under these conditions, but that fibrin, once formed, is not able to polymerize due to interference by iodopeptide. Similar results were obtained with heparin in vitro with thrombin-fibrinogen mixtures in the absence of NaCl. Studies with Russell’s viper venom in native PRP strongly suggest that the iodopeptide also interferes with processes in the early coagulation pathway associated with prothrombin activation." @default.
- W2443669561 created "2016-06-24" @default.
- W2443669561 creator A5018510722 @default.
- W2443669561 creator A5069712473 @default.
- W2443669561 date "1976-01-01" @default.
- W2443669561 modified "2023-10-17" @default.
- W2443669561 title "Studies on the Action Mechanism of the Antihemostatic Effect of lodopeptides" @default.
- W2443669561 doi "https://doi.org/10.1055/s-0038-1647938" @default.
- W2443669561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9704" @default.
- W2443669561 hasPublicationYear "1976" @default.
- W2443669561 type Work @default.
- W2443669561 sameAs 2443669561 @default.
- W2443669561 citedByCount "0" @default.
- W2443669561 crossrefType "journal-article" @default.
- W2443669561 hasAuthorship W2443669561A5018510722 @default.
- W2443669561 hasAuthorship W2443669561A5069712473 @default.
- W2443669561 hasConcept C12554922 @default.
- W2443669561 hasConcept C126322002 @default.
- W2443669561 hasConcept C150903083 @default.
- W2443669561 hasConcept C185592680 @default.
- W2443669561 hasConcept C202751555 @default.
- W2443669561 hasConcept C203014093 @default.
- W2443669561 hasConcept C207001950 @default.
- W2443669561 hasConcept C2776120743 @default.
- W2443669561 hasConcept C2777292125 @default.
- W2443669561 hasConcept C2777557582 @default.
- W2443669561 hasConcept C2778382381 @default.
- W2443669561 hasConcept C2779036427 @default.
- W2443669561 hasConcept C2779448229 @default.
- W2443669561 hasConcept C54173615 @default.
- W2443669561 hasConcept C55493867 @default.
- W2443669561 hasConcept C71924100 @default.
- W2443669561 hasConcept C86803240 @default.
- W2443669561 hasConcept C89560881 @default.
- W2443669561 hasConcept C98274493 @default.
- W2443669561 hasConceptScore W2443669561C12554922 @default.
- W2443669561 hasConceptScore W2443669561C126322002 @default.
- W2443669561 hasConceptScore W2443669561C150903083 @default.
- W2443669561 hasConceptScore W2443669561C185592680 @default.
- W2443669561 hasConceptScore W2443669561C202751555 @default.
- W2443669561 hasConceptScore W2443669561C203014093 @default.
- W2443669561 hasConceptScore W2443669561C207001950 @default.
- W2443669561 hasConceptScore W2443669561C2776120743 @default.
- W2443669561 hasConceptScore W2443669561C2777292125 @default.
- W2443669561 hasConceptScore W2443669561C2777557582 @default.
- W2443669561 hasConceptScore W2443669561C2778382381 @default.
- W2443669561 hasConceptScore W2443669561C2779036427 @default.
- W2443669561 hasConceptScore W2443669561C2779448229 @default.
- W2443669561 hasConceptScore W2443669561C54173615 @default.
- W2443669561 hasConceptScore W2443669561C55493867 @default.
- W2443669561 hasConceptScore W2443669561C71924100 @default.
- W2443669561 hasConceptScore W2443669561C86803240 @default.
- W2443669561 hasConceptScore W2443669561C89560881 @default.
- W2443669561 hasConceptScore W2443669561C98274493 @default.
- W2443669561 hasIssue "02" @default.
- W2443669561 hasLocation W24436695611 @default.
- W2443669561 hasOpenAccess W2443669561 @default.
- W2443669561 hasPrimaryLocation W24436695611 @default.
- W2443669561 hasRelatedWork W1999071152 @default.
- W2443669561 hasRelatedWork W2006279291 @default.
- W2443669561 hasRelatedWork W2017755911 @default.
- W2443669561 hasRelatedWork W2076346051 @default.
- W2443669561 hasRelatedWork W2131789611 @default.
- W2443669561 hasRelatedWork W2306671700 @default.
- W2443669561 hasRelatedWork W2330124581 @default.
- W2443669561 hasRelatedWork W2464800971 @default.
- W2443669561 hasRelatedWork W2905530978 @default.
- W2443669561 hasRelatedWork W4242628772 @default.
- W2443669561 hasVolume "35" @default.
- W2443669561 isParatext "false" @default.
- W2443669561 isRetracted "false" @default.
- W2443669561 magId "2443669561" @default.
- W2443669561 workType "article" @default.