Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443710812> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2443710812 endingPage "564" @default.
- W2443710812 startingPage "559" @default.
- W2443710812 abstract "1. The release of glutathione has been studied in comparison with the release of creatine kinase from isolated rat soleus muscles subjected to certain forms of experimental damage. 2. Excessive electrically stimulated contractile activity or treatment of muscles with the mitochondrial inhibitor, 2,4-dinitrophenol, induced a substantial release of both creatine kinase and glutathione and a reduction in the total glutathione content of the muscle. The time course of this release and depletion indicates that the efflux of the two molecules is not directly related and that a reduction in muscle glutathione content does not occur before cytosolic enzyme release. 3. 2,4-Dinitrophenol-stimulated release of creatine kinase was significantly reduced by the omission of external calcium from the incubation media, but glutathione release and depletion was relatively unaffected by this. Deliberate elevation of the muscle intracellular calcium content with the calcium ionophore, A23187, induced a substantial loss of creatine kinase, but had no significant effect on the release of glutathione. 4. Muscle biopsies from patients with Duchenne muscular dystrophy were found to have an elevated content of glutathione and an equivalent protein-thiol content compared with control subjects. 5. We conclude that, although release of glutathione from skeletal muscle occurs after excessive contractile activity or inhibition of mitochondrial metabolism, this is not a key step in the damaging processes leading to cytosolic enzyme release, neither is it relevant to the ongoing damage to skeletal muscle which occurs in patients with Duchenne muscular dystrophy." @default.
- W2443710812 created "2016-06-24" @default.
- W2443710812 creator A5013938912 @default.
- W2443710812 creator A5020213561 @default.
- W2443710812 creator A5059196642 @default.
- W2443710812 creator A5069088813 @default.
- W2443710812 date "1991-06-01" @default.
- W2443710812 modified "2023-09-27" @default.
- W2443710812 title "Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy" @default.
- W2443710812 doi "https://doi.org/10.1042/cs0800559" @default.
- W2443710812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1647917" @default.
- W2443710812 hasPublicationYear "1991" @default.
- W2443710812 type Work @default.
- W2443710812 sameAs 2443710812 @default.
- W2443710812 citedByCount "9" @default.
- W2443710812 countsByYear W24437108122012 @default.
- W2443710812 crossrefType "journal-article" @default.
- W2443710812 hasAuthorship W2443710812A5013938912 @default.
- W2443710812 hasAuthorship W2443710812A5020213561 @default.
- W2443710812 hasAuthorship W2443710812A5059196642 @default.
- W2443710812 hasAuthorship W2443710812A5069088813 @default.
- W2443710812 hasConcept C126322002 @default.
- W2443710812 hasConcept C134018914 @default.
- W2443710812 hasConcept C181199279 @default.
- W2443710812 hasConcept C185592680 @default.
- W2443710812 hasConcept C2778943923 @default.
- W2443710812 hasConcept C2779030066 @default.
- W2443710812 hasConcept C2779179908 @default.
- W2443710812 hasConcept C2779959927 @default.
- W2443710812 hasConcept C36880943 @default.
- W2443710812 hasConcept C538909803 @default.
- W2443710812 hasConcept C55493867 @default.
- W2443710812 hasConcept C71924100 @default.
- W2443710812 hasConcept C86803240 @default.
- W2443710812 hasConcept C98539663 @default.
- W2443710812 hasConceptScore W2443710812C126322002 @default.
- W2443710812 hasConceptScore W2443710812C134018914 @default.
- W2443710812 hasConceptScore W2443710812C181199279 @default.
- W2443710812 hasConceptScore W2443710812C185592680 @default.
- W2443710812 hasConceptScore W2443710812C2778943923 @default.
- W2443710812 hasConceptScore W2443710812C2779030066 @default.
- W2443710812 hasConceptScore W2443710812C2779179908 @default.
- W2443710812 hasConceptScore W2443710812C2779959927 @default.
- W2443710812 hasConceptScore W2443710812C36880943 @default.
- W2443710812 hasConceptScore W2443710812C538909803 @default.
- W2443710812 hasConceptScore W2443710812C55493867 @default.
- W2443710812 hasConceptScore W2443710812C71924100 @default.
- W2443710812 hasConceptScore W2443710812C86803240 @default.
- W2443710812 hasConceptScore W2443710812C98539663 @default.
- W2443710812 hasIssue "6" @default.
- W2443710812 hasLocation W24437108121 @default.
- W2443710812 hasLocation W24437108122 @default.
- W2443710812 hasOpenAccess W2443710812 @default.
- W2443710812 hasPrimaryLocation W24437108121 @default.
- W2443710812 hasRelatedWork W2021466601 @default.
- W2443710812 hasRelatedWork W2027384025 @default.
- W2443710812 hasRelatedWork W2030746296 @default.
- W2443710812 hasRelatedWork W2039154047 @default.
- W2443710812 hasRelatedWork W2089379767 @default.
- W2443710812 hasRelatedWork W2166810075 @default.
- W2443710812 hasRelatedWork W2327262010 @default.
- W2443710812 hasRelatedWork W2443710812 @default.
- W2443710812 hasRelatedWork W3135421668 @default.
- W2443710812 hasRelatedWork W4317914514 @default.
- W2443710812 hasVolume "80" @default.
- W2443710812 isParatext "false" @default.
- W2443710812 isRetracted "false" @default.
- W2443710812 magId "2443710812" @default.
- W2443710812 workType "article" @default.