Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443896190> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2443896190 endingPage "31" @default.
- W2443896190 startingPage "23" @default.
- W2443896190 abstract "Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5-HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P < 0.0001), rs6295G/G (P < 0.0001) and rs1364043T/T (P = 0.018) genotype carriers, independently from clinical variables. Furthermore minor allele homozygous carriers in all these 3 SNPs were associated with treatment response by various assessments such as HAM-D score change over time (P = 0.001), week 2 (P < 0.0001), 4 (P = 0.007), and 6 (P = 0.048) as well as response rate (P = 0.0005) and remission rate (P = 0.004). We also pointed out the genotyping mis-definition of rs6295C/G in the previous four papers." @default.
- W2443896190 created "2016-06-24" @default.
- W2443896190 creator A5009945280 @default.
- W2443896190 creator A5029514198 @default.
- W2443896190 creator A5032624282 @default.
- W2443896190 creator A5058118992 @default.
- W2443896190 creator A5060685026 @default.
- W2443896190 creator A5060692693 @default.
- W2443896190 creator A5079520465 @default.
- W2443896190 creator A5087281969 @default.
- W2443896190 date "2009-02-01" @default.
- W2443896190 modified "2023-09-23" @default.
- W2443896190 title "[5-HT1A gene polymorphisms contributed to antidepressant response in major depression]." @default.
- W2443896190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19326813" @default.
- W2443896190 hasPublicationYear "2009" @default.
- W2443896190 type Work @default.
- W2443896190 sameAs 2443896190 @default.
- W2443896190 citedByCount "1" @default.
- W2443896190 countsByYear W24438961902016 @default.
- W2443896190 crossrefType "journal-article" @default.
- W2443896190 hasAuthorship W2443896190A5009945280 @default.
- W2443896190 hasAuthorship W2443896190A5029514198 @default.
- W2443896190 hasAuthorship W2443896190A5032624282 @default.
- W2443896190 hasAuthorship W2443896190A5058118992 @default.
- W2443896190 hasAuthorship W2443896190A5060685026 @default.
- W2443896190 hasAuthorship W2443896190A5060692693 @default.
- W2443896190 hasAuthorship W2443896190A5079520465 @default.
- W2443896190 hasAuthorship W2443896190A5087281969 @default.
- W2443896190 hasConcept C104317684 @default.
- W2443896190 hasConcept C126322002 @default.
- W2443896190 hasConcept C135763542 @default.
- W2443896190 hasConcept C139275648 @default.
- W2443896190 hasConcept C139719470 @default.
- W2443896190 hasConcept C143998085 @default.
- W2443896190 hasConcept C153209595 @default.
- W2443896190 hasConcept C162324750 @default.
- W2443896190 hasConcept C180754005 @default.
- W2443896190 hasConcept C186413461 @default.
- W2443896190 hasConcept C2776867660 @default.
- W2443896190 hasConcept C2779177272 @default.
- W2443896190 hasConcept C2781161787 @default.
- W2443896190 hasConcept C31467283 @default.
- W2443896190 hasConcept C35605836 @default.
- W2443896190 hasConcept C54355233 @default.
- W2443896190 hasConcept C71924100 @default.
- W2443896190 hasConcept C86803240 @default.
- W2443896190 hasConcept C98274493 @default.
- W2443896190 hasConceptScore W2443896190C104317684 @default.
- W2443896190 hasConceptScore W2443896190C126322002 @default.
- W2443896190 hasConceptScore W2443896190C135763542 @default.
- W2443896190 hasConceptScore W2443896190C139275648 @default.
- W2443896190 hasConceptScore W2443896190C139719470 @default.
- W2443896190 hasConceptScore W2443896190C143998085 @default.
- W2443896190 hasConceptScore W2443896190C153209595 @default.
- W2443896190 hasConceptScore W2443896190C162324750 @default.
- W2443896190 hasConceptScore W2443896190C180754005 @default.
- W2443896190 hasConceptScore W2443896190C186413461 @default.
- W2443896190 hasConceptScore W2443896190C2776867660 @default.
- W2443896190 hasConceptScore W2443896190C2779177272 @default.
- W2443896190 hasConceptScore W2443896190C2781161787 @default.
- W2443896190 hasConceptScore W2443896190C31467283 @default.
- W2443896190 hasConceptScore W2443896190C35605836 @default.
- W2443896190 hasConceptScore W2443896190C54355233 @default.
- W2443896190 hasConceptScore W2443896190C71924100 @default.
- W2443896190 hasConceptScore W2443896190C86803240 @default.
- W2443896190 hasConceptScore W2443896190C98274493 @default.
- W2443896190 hasIssue "1" @default.
- W2443896190 hasLocation W24438961901 @default.
- W2443896190 hasLocation W24438961902 @default.
- W2443896190 hasOpenAccess W2443896190 @default.
- W2443896190 hasPrimaryLocation W24438961901 @default.
- W2443896190 hasRelatedWork W1986920358 @default.
- W2443896190 hasRelatedWork W2017179477 @default.
- W2443896190 hasRelatedWork W2019560834 @default.
- W2443896190 hasRelatedWork W2028184718 @default.
- W2443896190 hasRelatedWork W2034212588 @default.
- W2443896190 hasRelatedWork W2039635132 @default.
- W2443896190 hasRelatedWork W2053626252 @default.
- W2443896190 hasRelatedWork W2057422067 @default.
- W2443896190 hasRelatedWork W2360156487 @default.
- W2443896190 hasRelatedWork W2368882077 @default.
- W2443896190 hasRelatedWork W2543824821 @default.
- W2443896190 hasRelatedWork W2909403953 @default.
- W2443896190 hasRelatedWork W2914324052 @default.
- W2443896190 hasRelatedWork W296220788 @default.
- W2443896190 hasRelatedWork W3013362441 @default.
- W2443896190 hasRelatedWork W3031367126 @default.
- W2443896190 hasRelatedWork W3031960764 @default.
- W2443896190 hasRelatedWork W3046110110 @default.
- W2443896190 hasRelatedWork W3049417117 @default.
- W2443896190 hasRelatedWork W3089289985 @default.
- W2443896190 hasVolume "29" @default.
- W2443896190 isParatext "false" @default.
- W2443896190 isRetracted "false" @default.
- W2443896190 magId "2443896190" @default.
- W2443896190 workType "article" @default.