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- W2443927686 abstract "Objective- This study aimed to investigate the effect of topical administration of lintbells oil (LBOC) on wound contraction as well as healing process. Design- Experimental study. Animals- 60 Male Swiss albino mice. Procedures- Animals were randomly divided into 5 groups (NO=12) including; vehicle-received negative control, pure oil-received and test group. The animals in treatment group subdivided into two groups as 2% cream-treated (LBOC 2%) and 4% cream-treated (LBOC 4%).Two circular full thickness skin defects were made, in both sides of the backbone, 1 cm away from the midline and 2 cm away from each other with a 5-mm-biopsy punch. Using graph paper, the Percentage of wound contraction measured at 3 rd , 6 th , 9 th and 12 th days after surgery. Tissue samples were obtained at the3 rd , 6 th and12 th days postwounding, from all groups and stained with Masson’s trichrome and studied under light microscope. Results- In LBOC treated groups, the healing process shortened significantly, which was revealed with rapid reduction of wound area. Histological observations revealed that, LBOC in form of 2%formulation remarkably reduced inflammatory cells infiltration, enhanced collagen deposition and facilitated the epithelialization versus other groups. Conclusion and Clinical Relevance- In conclusion, our data showed that lintbells oil, especially in 2% doses, promotes wound contraction ratio and facilitated the healing processes by inhibiting the inflammatory stage and stimulated the prolifrative phase by enhancing the fibroblasts distribution and/or" @default.
- W2443927686 created "2016-06-24" @default.
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- W2443927686 date "2014-01-01" @default.
- W2443927686 modified "2023-09-26" @default.
- W2443927686 title "The Evaluation of Topical Administration of Different Doses of Lintbells Oil on Circular Excisional Wound Healing in Experimental Models" @default.
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