Matches in SemOpenAlex for { <https://semopenalex.org/work/W2443941129> ?p ?o ?g. }
- W2443941129 abstract "Previous studies from this and other laboratories have shown that angiotensin II (AII) induces [Ca2j transients in proximal tubular epithelium independent of phospholipase C. AII also stimulates formation of 5,6-epoxyeicosatrienoic acid (5,6EET) from arachidonic acid by a cytochrome P450 epoxygenase and decreases Na' transport in the same concentration range. Because 5,6-EET mimics AII with regard to Na' transport, its effects on calcium mobilization were evaluated. ICa2i, was measured by video microscopy with the fluorescent indicator fura-2 employing cultured rabbit proximal tubule. AII-induced ICa2+i transients were enhanced by arachidonic acid and attenuated by ketoconazole, an inhibitor of cytochrome P450 epoxygenases. Arachidonic acid also elicited a ICa2i1, transient that was attenuated by ketoconazole. 5,6-EET augmented (Ca2'], similar to that seen with AII, but was unaffected by ketoconazole. By contrast, the other regioisomers (8,9-, 11,12-, and 14,15-EET) were much less potent. ICa2+i, transients resulted from influx through verapamil- and nifedipine-sensitive channels. These results suggest a novel mechanism for AII-induced Ca mobilization in proximal tubule involving cytochrome P450-dependent arachidonic asid metabolism and Ca influx" @default.
- W2443941129 created "2016-06-24" @default.
- W2443941129 creator A5026958024 @default.
- W2443941129 creator A5071484132 @default.
- W2443941129 creator A5072774542 @default.
- W2443941129 creator A5083084588 @default.
- W2443941129 creator A5070523425 @default.
- W2443941129 date "1991-01-01" @default.
- W2443941129 modified "2023-09-27" @default.
- W2443941129 title "Il-induced Rises in Cytosolic Calcium in Rabbit Proximal Tubule Epithelial Cells" @default.
- W2443941129 cites W1156084614 @default.
- W2443941129 cites W1261423890 @default.
- W2443941129 cites W1483682996 @default.
- W2443941129 cites W1512774268 @default.
- W2443941129 cites W1598617305 @default.
- W2443941129 cites W1969455975 @default.
- W2443941129 cites W1984329967 @default.
- W2443941129 cites W1990930369 @default.
- W2443941129 cites W1991631709 @default.
- W2443941129 cites W1992635534 @default.
- W2443941129 cites W1993260144 @default.
- W2443941129 cites W1999557771 @default.
- W2443941129 cites W2011918618 @default.
- W2443941129 cites W2042616274 @default.
- W2443941129 cites W2046481283 @default.
- W2443941129 cites W2046649233 @default.
- W2443941129 cites W2050835069 @default.
- W2443941129 cites W2051581461 @default.
- W2443941129 cites W2066225691 @default.
- W2443941129 cites W2074003314 @default.
- W2443941129 cites W2077284332 @default.
- W2443941129 cites W2077754117 @default.
- W2443941129 cites W2077785024 @default.
- W2443941129 cites W2078118683 @default.
- W2443941129 cites W2095331491 @default.
- W2443941129 cites W2114271690 @default.
- W2443941129 cites W2130909012 @default.
- W2443941129 cites W2141260882 @default.
- W2443941129 cites W2154595354 @default.
- W2443941129 cites W2206398780 @default.
- W2443941129 cites W2234097292 @default.
- W2443941129 cites W2335131022 @default.
- W2443941129 cites W2336735632 @default.
- W2443941129 cites W2413211091 @default.
- W2443941129 cites W2417520021 @default.
- W2443941129 cites W2437114177 @default.
- W2443941129 cites W57370797 @default.
- W2443941129 hasPublicationYear "1991" @default.
- W2443941129 type Work @default.
- W2443941129 sameAs 2443941129 @default.
- W2443941129 citedByCount "0" @default.
- W2443941129 crossrefType "journal-article" @default.
- W2443941129 hasAuthorship W2443941129A5026958024 @default.
- W2443941129 hasAuthorship W2443941129A5070523425 @default.
- W2443941129 hasAuthorship W2443941129A5071484132 @default.
- W2443941129 hasAuthorship W2443941129A5072774542 @default.
- W2443941129 hasAuthorship W2443941129A5083084588 @default.
- W2443941129 hasConcept C126322002 @default.
- W2443941129 hasConcept C134018914 @default.
- W2443941129 hasConcept C170493617 @default.
- W2443941129 hasConcept C181199279 @default.
- W2443941129 hasConcept C185592680 @default.
- W2443941129 hasConcept C2776352881 @default.
- W2443941129 hasConcept C2777022698 @default.
- W2443941129 hasConcept C2778078955 @default.
- W2443941129 hasConcept C2779396086 @default.
- W2443941129 hasConcept C2908929049 @default.
- W2443941129 hasConcept C519063684 @default.
- W2443941129 hasConcept C526171541 @default.
- W2443941129 hasConcept C55493867 @default.
- W2443941129 hasConcept C62231903 @default.
- W2443941129 hasConcept C71924100 @default.
- W2443941129 hasConcept C86803240 @default.
- W2443941129 hasConceptScore W2443941129C126322002 @default.
- W2443941129 hasConceptScore W2443941129C134018914 @default.
- W2443941129 hasConceptScore W2443941129C170493617 @default.
- W2443941129 hasConceptScore W2443941129C181199279 @default.
- W2443941129 hasConceptScore W2443941129C185592680 @default.
- W2443941129 hasConceptScore W2443941129C2776352881 @default.
- W2443941129 hasConceptScore W2443941129C2777022698 @default.
- W2443941129 hasConceptScore W2443941129C2778078955 @default.
- W2443941129 hasConceptScore W2443941129C2779396086 @default.
- W2443941129 hasConceptScore W2443941129C2908929049 @default.
- W2443941129 hasConceptScore W2443941129C519063684 @default.
- W2443941129 hasConceptScore W2443941129C526171541 @default.
- W2443941129 hasConceptScore W2443941129C55493867 @default.
- W2443941129 hasConceptScore W2443941129C62231903 @default.
- W2443941129 hasConceptScore W2443941129C71924100 @default.
- W2443941129 hasConceptScore W2443941129C86803240 @default.
- W2443941129 hasLocation W24439411291 @default.
- W2443941129 hasOpenAccess W2443941129 @default.
- W2443941129 hasPrimaryLocation W24439411291 @default.
- W2443941129 hasRelatedWork W1586659225 @default.
- W2443941129 hasRelatedWork W1596278630 @default.
- W2443941129 hasRelatedWork W1979853472 @default.
- W2443941129 hasRelatedWork W1999110844 @default.
- W2443941129 hasRelatedWork W2012861488 @default.
- W2443941129 hasRelatedWork W2051280838 @default.
- W2443941129 hasRelatedWork W2078671936 @default.
- W2443941129 hasRelatedWork W2085992470 @default.