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• W2444082743 abstract "Sphingomyelin-rich microdomains have been observed in the biological membrane surrounding milk fat globules (MFGM). The role played by cholesterol in these domains and in the physical properties and functions of the MFGM remains poorly understood. The objective of this work was therefore to investigate the phase state, topography, and mechanical properties of MFGM polar lipid bilayers as a function of cholesterol concentration, by combining X-ray diffraction, atomic force microscopy imaging, and force spectroscopy. At room temperature, i.e. below the phase transition temperature of the MFGM polar lipids, the bilayers showed the formation of sphingomyelin-rich domains in the solid ordered (so) phase that protruded about 1 nm above the liquid disordered (ld) phase. These so phase domains have a higher mechanical resistance to rupture than the ld phase (30 nN versus 15 nN). Addition of cholesterol in the MFGM polar lipid bilayers (i) induced the formation of liquid ordered (lo) phase for up to 27 mol % in the bilayers, (ii) decreased the height difference between the thicker ordered domains and the surrounding ld phase, (iii) promoted the formation of small sized domains, and (iv) decreased the mechanical resistance to rupture of the sphingomyelin-rich domains down to ∼5 nN. The biological and functional relevance of the lo phase cholesterol/sphingomyelin-rich domains in the membrane surrounding fat globules in milk remains to be elucidated. This study brought new insight about the functional role of cholesterol in milk polar lipid ingredients, which can be used in the preparation of food emulsions, e.g. infant milk formulas." @default.
• W2444082743 created "2016-06-24" @default.
• W2444082743 creator A5064858329 @default.
• W2444082743 creator A5065779166 @default.
• W2444082743 creator A5084409279 @default.
• W2444082743 date "2016-06-23" @default.
• W2444082743 modified "2023-10-17" @default.
• W2444082743 title "Cholesterol Decreases the Size and the Mechanical Resistance to Rupture of Sphingomyelin Rich Domains, in Lipid Bilayers Studied as a Model of the Milk Fat Globule Membrane" @default.
• W2444082743 cites W128015626 @default.
• W2444082743 cites W1960856059 @default.
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• W2444082743 cites W1984715257 @default.
• W2444082743 cites W1986076971 @default.
• W2444082743 cites W1986324420 @default.
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• W2444082743 cites W1990394752 @default.
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• W2444082743 doi "https://doi.org/10.1021/acs.langmuir.6b01040" @default.
• W2444082743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27300157" @default.
• W2444082743 hasPublicationYear "2016" @default.
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