Matches in SemOpenAlex for { <https://semopenalex.org/work/W2444132783> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2444132783 endingPage "3" @default.
- W2444132783 startingPage "120" @default.
- W2444132783 abstract "Plasma praziquantel concentrations were measured in 11 Thai patients with active neurocysticercosis (8 males and 3 females). Praziquantel (Biltricide 600 mg per tablet) was given at a daily dose of 45 mg/kg given in 3 divided doses for 15 consecutive days. All patients had significant improvement with resolution of symptoms and signs, and reduction of active lesions of cysticercosis shown by the brain computed tomographic scanning. After oral administration, the drug was rapidly absorbed from the gastrointestinal tract. There was substantial inter-individual variability in plasma concentrations of praziquantel. After the first dose, maximum plasma concentrations in the range of 42-540 ng/ml was attained at 30 minutes to 5 hours. In all cases, the drug almost totally disappeared from plasma within 8 hours; drug levels measured prior to the first doses on the following days showed undetectable levels. The area under the plasma concentration-time curves of praziquantel following the first dose were between 125 and 990 ng hour/ml. The results suggested that the unusual low plasma availability of the drug observed in this group of patients could be a consequence of pharmacokinetic drug interactions of the concomitant therapy with antiepileptic drugs and dexamethasone. Active metabolite(s), rather than praziquantel itself, may play a significant part in the therapy of neurocysticerosis." @default.
- W2444132783 created "2016-06-24" @default.
- W2444132783 creator A5002736566 @default.
- W2444132783 creator A5044311962 @default.
- W2444132783 creator A5045836221 @default.
- W2444132783 date "1995-03-01" @default.
- W2444132783 modified "2023-09-27" @default.
- W2444132783 title "Plasma concentrations of praziquantel during the therapy of neurocysticerosis with praziquantel, in the presence of antiepileptics and dexamethasone." @default.
- W2444132783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8525397" @default.
- W2444132783 hasPublicationYear "1995" @default.
- W2444132783 type Work @default.
- W2444132783 sameAs 2444132783 @default.
- W2444132783 citedByCount "6" @default.
- W2444132783 countsByYear W24441327832013 @default.
- W2444132783 countsByYear W24441327832015 @default.
- W2444132783 countsByYear W24441327832016 @default.
- W2444132783 crossrefType "journal-article" @default.
- W2444132783 hasAuthorship W2444132783A5002736566 @default.
- W2444132783 hasAuthorship W2444132783A5044311962 @default.
- W2444132783 hasAuthorship W2444132783A5045836221 @default.
- W2444132783 hasConcept C112705442 @default.
- W2444132783 hasConcept C126322002 @default.
- W2444132783 hasConcept C142724271 @default.
- W2444132783 hasConcept C149151106 @default.
- W2444132783 hasConcept C162156334 @default.
- W2444132783 hasConcept C165901193 @default.
- W2444132783 hasConcept C203014093 @default.
- W2444132783 hasConcept C2776225656 @default.
- W2444132783 hasConcept C2776908094 @default.
- W2444132783 hasConcept C2778056992 @default.
- W2444132783 hasConcept C2779384505 @default.
- W2444132783 hasConcept C2779744950 @default.
- W2444132783 hasConcept C2780035454 @default.
- W2444132783 hasConcept C2780401358 @default.
- W2444132783 hasConcept C2780449708 @default.
- W2444132783 hasConcept C42972112 @default.
- W2444132783 hasConcept C71924100 @default.
- W2444132783 hasConcept C90924648 @default.
- W2444132783 hasConcept C98274493 @default.
- W2444132783 hasConceptScore W2444132783C112705442 @default.
- W2444132783 hasConceptScore W2444132783C126322002 @default.
- W2444132783 hasConceptScore W2444132783C142724271 @default.
- W2444132783 hasConceptScore W2444132783C149151106 @default.
- W2444132783 hasConceptScore W2444132783C162156334 @default.
- W2444132783 hasConceptScore W2444132783C165901193 @default.
- W2444132783 hasConceptScore W2444132783C203014093 @default.
- W2444132783 hasConceptScore W2444132783C2776225656 @default.
- W2444132783 hasConceptScore W2444132783C2776908094 @default.
- W2444132783 hasConceptScore W2444132783C2778056992 @default.
- W2444132783 hasConceptScore W2444132783C2779384505 @default.
- W2444132783 hasConceptScore W2444132783C2779744950 @default.
- W2444132783 hasConceptScore W2444132783C2780035454 @default.
- W2444132783 hasConceptScore W2444132783C2780401358 @default.
- W2444132783 hasConceptScore W2444132783C2780449708 @default.
- W2444132783 hasConceptScore W2444132783C42972112 @default.
- W2444132783 hasConceptScore W2444132783C71924100 @default.
- W2444132783 hasConceptScore W2444132783C90924648 @default.
- W2444132783 hasConceptScore W2444132783C98274493 @default.
- W2444132783 hasIssue "1" @default.
- W2444132783 hasLocation W24441327831 @default.
- W2444132783 hasOpenAccess W2444132783 @default.
- W2444132783 hasPrimaryLocation W24441327831 @default.
- W2444132783 hasRelatedWork W1998029765 @default.
- W2444132783 hasRelatedWork W2006471797 @default.
- W2444132783 hasRelatedWork W2010772468 @default.
- W2444132783 hasRelatedWork W2052711211 @default.
- W2444132783 hasRelatedWork W2070605637 @default.
- W2444132783 hasRelatedWork W2143027086 @default.
- W2444132783 hasRelatedWork W2362974908 @default.
- W2444132783 hasRelatedWork W2410985630 @default.
- W2444132783 hasRelatedWork W2412637240 @default.
- W2444132783 hasRelatedWork W2444132783 @default.
- W2444132783 hasVolume "26" @default.
- W2444132783 isParatext "false" @default.
- W2444132783 isRetracted "false" @default.
- W2444132783 magId "2444132783" @default.
- W2444132783 workType "article" @default.