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- W2444148625 abstract "GnRH agonists represent the most definitive method available for disrupting ovarian steroidogenesis to induce resolution of endometriosis. Clinical studies have documented a favorable response as assessed by a decrease in implant size and an improvement in pelvic pain and dyspareunia. Endometriomas and severe adhesive disease do not respond to GnRH-a therapy. The available data indicate that GnRH-a are comparable to danazol in treating all symptoms of endometriosis. Data addressing fertility potential are preliminary and short-term, but they do support a continued role for GnRH-a treatment. Currently, no reports address the frequency of spontaneous abortion, ectopic pregnancy, and abnormal offspring following treatment. Similarly, little information is available regarding recurrence rates, but they should be comparable to those of danazol. The principal advantages of GnRH-a therapy are fewer, milder, and less bothersome side effects. The specificity of GnRH-a for the pituitary-ovarian axis and the rapid reversibility of clinical effects following cessation of therapy are additional benefits. No specific GnRH-a has been demonstrated to have any clear, unique advantage over other GnRH-a agents. Additional study should more precisely define the role of GnRH-a therapy and provide answers to issues such as the value of GnRH-a therapy before and after surgery, optimum duration of therapy, and the value of progestin adjuvant therapy in minimizing vasomotor symptoms and skeletal calcium loss." @default.
- W2444148625 created "2016-06-24" @default.
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- W2444148625 date "1989-03-01" @default.
- W2444148625 modified "2023-10-17" @default.
- W2444148625 title "GnRH Analogues in the Treatment of Endometriosis" @default.
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- W2444148625 doi "https://doi.org/10.1016/s0889-8545(21)00142-x" @default.
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