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- W2444299872 abstract "We analyzed the results of 85 treatments with carbimazol in 71 patients with Graves' disease. The initial dose ranged from 45 to 60 mg/day, which was gradually reduced to the lowest possible maintenance dose; the mean treatment period was 17 months. All patients achieved euthyroid function after 12 weeks at the latest. Normalization of the pituitary TSH-reserve occurred late (after 6-12 months in most cases). 60% of the patients treated for the first time (n = 58) and 59% of the whole group remained in remission. The maintenance dose of carbimazol had no effect on the rate of remission. It is interesting to note that in 66% of the patients a very low dose (less than or equal to 5 mg/day) was fully effective and resulted in a remission rate of 54%. Therefore, the dose should always be reduced individually. Relapses occurred within the first year after the end of treatment in 77% of the cases, but were also observed after 2-3 years. Hence follow-up should be continued after cessation of therapy." @default.
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- W2444299872 date "1989-12-30" @default.
- W2444299872 modified "2023-09-26" @default.
- W2444299872 title "[Carbimazole therapy in Basedow's disease: therapy results in individual dosage adjustment]." @default.
- W2444299872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2609144" @default.
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