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- W2445023 endingPage "187" @default.
- W2445023 startingPage "154" @default.
- W2445023 abstract "This chapter focuses on the target of various bacterial toxins and secreted effector molecules, as well as eucaryotic actin, which assembles into organized filaments regulated by a variety of cytoskeletal proteins. Actin filaments can form a dynamic meshwork within a cell that extends throughout the cytosol (stress fibers) and underneath the plasma membrane (cortical actin), thus representing the main structure responsible for eucaryotic cell morphology The actin-based cytoskeleton also controls many cellular functions critical for eucaryotic life including locomotion, endocytosis, exocytosis, trafficking of intracellular organelles, as well as maintenance of intercellular connections known as tight (TJs) and adherens (AJs) junctions. From the pathogen's perspective, an ability to manipulate the host is desirable for obtaining additional nutrients, avoiding the immune system, and ultimately disseminating to a new host. Among the numerous partners responsible for actin regulation, procaryotic toxins and virulence factors act at two levels that involve actin monomers and Rho-GTPases. Toxins that directly target actin molecules rapidly disrupt the entire actin cytoskeleton, which is concomitant with a brutal and drastic rupture of cell barrier integrity. In contrast, toxins and virulence factors acting on Rho- GTPases modulate specific cellular functions, thus allowing pathogens to alter certain intercellular junctions or to cross through cell barriers and escape host mechanisms of defense." @default.
- W2445023 created "2016-06-24" @default.
- W2445023 creator A5017076724 @default.
- W2445023 creator A5019497452 @default.
- W2445023 date "2006-01-01" @default.
- W2445023 modified "2023-10-18" @default.
- W2445023 title "Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular junctions" @default.
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