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• W244549403 abstract "Research Article1 December 1991free access Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors. L. Shemshedini L. Shemshedini Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author R. Knauthe R. Knauthe Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author P. Sassone-Corsi P. Sassone-Corsi Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author A. Pornon A. Pornon Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author H. Gronemeyer H. Gronemeyer Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author L. Shemshedini L. Shemshedini Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author R. Knauthe R. Knauthe Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author P. Sassone-Corsi P. Sassone-Corsi Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author A. Pornon A. Pornon Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author H. Gronemeyer H. Gronemeyer Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. Search for more papers by this author Author Information L. Shemshedini1, R. Knauthe1, P. Sassone-Corsi1, A. Pornon1 and H. Gronemeyer1 1Laboratoire de Génétique Moléculaire des Eucaryotes, CNRS, Strasbourg, France. The EMBO Journal (1991)10:3839-3849https://doi.org/10.1002/j.1460-2075.1991.tb04953.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We investigated the effect of c-Fos and/or c-Jun co-expression on transcription activation by the progesterone (PR), glucocorticoid (GR) or androgen (AR) receptors using three different reporter genes and four different cell lines. We found that c-Fos could only inhibit, while c-Jun could either inhibit or further stimulate receptor-induced transcription. All these effects were receptor, promoter, and cell type specific, and, importantly, the steroid receptors had non-reciprocal effects on the transactivation ability of c-Jun in the presence or absence of c-Fos. Collectively, these results argue against heterodimer formation as a mechanism to explain the phenomena. Transactivation by the endogenous PR in T47D cells could be inhibited by increasing the intracellular c-Fos level with forskolin as well as by co-expressing c-Fos; no such effect was seen in MCF-7 cells. The inhibition by c-Fos of PR-induced transcription involves a competitive mechanism, which requires the presence of the intact c-Fos leucine zipper and is directed mainly at the transcription activation function (TAF) located in the PR and GR hormone binding domains (TAF-2). However, the co-expression of c-Fos did not alter the ‘squelching/transcriptional interference’ by the PR of estrogen receptor (ER)-induced transcription. Multiple mechanisms are discussed which may be involved in the crosstalk between the two signal transduction pathways. Previous ArticleNext Article Volume 10Issue 121 December 1991In this issue RelatedDetailsLoading ..." @default.
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• W244549403 date "1991-12-01" @default.
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• W244549403 title "Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors." @default.
• W244549403 cites W1481038980 @default.
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• W244549403 cites W1562960938 @default.
• W244549403 cites W1571431043 @default.
• W244549403 cites W1598886839 @default.
• W244549403 cites W1670076014 @default.
• W244549403 cites W1821731873 @default.
• W244549403 cites W1843244908 @default.
• W244549403 cites W1940502884 @default.
• W244549403 cites W1967004332 @default.
• W244549403 cites W1971960644 @default.
• W244549403 cites W1977347668 @default.
• W244549403 cites W1979419333 @default.
• W244549403 cites W1979647722 @default.
• W244549403 cites W1979801990 @default.
• W244549403 cites W1980722886 @default.
• W244549403 cites W1987557547 @default.
• W244549403 cites W1997031612 @default.
• W244549403 cites W1997514802 @default.
• W244549403 cites W1998861020 @default.
• W244549403 cites W2000371106 @default.
• W244549403 cites W2001859124 @default.
• W244549403 cites W2005393972 @default.
• W244549403 cites W2005914718 @default.
• W244549403 cites W2008822380 @default.
• W244549403 cites W2010234214 @default.
• W244549403 cites W2010326135 @default.
• W244549403 cites W2011158289 @default.
• W244549403 cites W2012533550 @default.
• W244549403 cites W2014107736 @default.
• W244549403 cites W2019709308 @default.
• W244549403 cites W2021893003 @default.
• W244549403 cites W2022315433 @default.
• W244549403 cites W2027216583 @default.
• W244549403 cites W2028507406 @default.
• W244549403 cites W2029475329 @default.
• W244549403 cites W2033777731 @default.
• W244549403 cites W2037404178 @default.
• W244549403 cites W2045798063 @default.
• W244549403 cites W2060484288 @default.
• W244549403 cites W2060903877 @default.
• W244549403 cites W2063110155 @default.
• W244549403 cites W2064089886 @default.
• W244549403 cites W2066441904 @default.
• W244549403 cites W2068609431 @default.
• W244549403 cites W2070633083 @default.
• W244549403 cites W2077679480 @default.
• W244549403 cites W2078312579 @default.
• W244549403 cites W2081135713 @default.
• W244549403 cites W2081501399 @default.
• W244549403 cites W2085124463 @default.
• W244549403 cites W2097483036 @default.
• W244549403 cites W2107620873 @default.
• W244549403 cites W2118870434 @default.
• W244549403 cites W2119725374 @default.
• W244549403 cites W2125013861 @default.
• W244549403 cites W2131695882 @default.
• W244549403 cites W2159545772 @default.
• W244549403 cites W241168973 @default.
• W244549403 cites W2415563874 @default.
• W244549403 cites W2416240605 @default.
• W244549403 cites W2418007510 @default.
• W244549403 cites W260259550 @default.
• W244549403 cites W4290293655 @default.
• W244549403 cites W69763153 @default.
• W244549403 cites W74071586 @default.
• W244549403 doi "https://doi.org/10.1002/j.1460-2075.1991.tb04953.x" @default.
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