Matches in SemOpenAlex for { <https://semopenalex.org/work/W244559346> ?p ?o ?g. }
- W244559346 endingPage "e0127197" @default.
- W244559346 startingPage "e0127197" @default.
- W244559346 abstract "Helicobacter pylori, a bacterial pathogen that can infect human stomach causing gastritis, ulcers and cancer, is known to have a high degree of genome/epigenome diversity as the result of mutation and recombination. The bacteria often infect in childhood and persist for the life of the host. One of the reasons of the rapid evolution of H. pylori is that it changes its genome drastically for adaptation to a new host. To investigate microevolution and adaptation of the H. pylori genome, we undertook whole genome sequencing of the same or very similar sequence type in multi-locus sequence typing (MLST) with seven genes in members of the same family consisting of parents and children in Japan. Detection of nucleotide substitutions revealed likely transmission pathways involving children. Nonsynonymous (amino acid changing) mutations were found in virulence-related genes (cag genes, vacA, hcpDX, tnfα, ggt, htrA and the collagenase gene), outer membrane protein (OMP) genes and other cell surface-related protein genes, signal transduction genes and restriction-modification genes. We reconstructed various pathways by which H. pylori can adapt to a new human host, and our results raised the possibility that the mutational changes in virulence-related genes have a role in adaptation to a child host. Changes in restriction-modification genes might remodel the methylome and transcriptome to help adaptation. This study has provided insights into H. pylori transmission and virulence and has implications for basic research as well as clinical practice." @default.
- W244559346 created "2016-06-24" @default.
- W244559346 creator A5001042153 @default.
- W244559346 creator A5004700592 @default.
- W244559346 creator A5016112782 @default.
- W244559346 creator A5022775273 @default.
- W244559346 creator A5030469168 @default.
- W244559346 creator A5036776546 @default.
- W244559346 creator A5047403424 @default.
- W244559346 creator A5048640463 @default.
- W244559346 creator A5056381274 @default.
- W244559346 creator A5058856297 @default.
- W244559346 creator A5075908089 @default.
- W244559346 creator A5091720329 @default.
- W244559346 date "2015-05-15" @default.
- W244559346 modified "2023-10-17" @default.
- W244559346 title "Microevolution of Virulence-Related Genes in Helicobacter pylori Familial Infection" @default.
- W244559346 cites W1531344891 @default.
- W244559346 cites W1603009641 @default.
- W244559346 cites W1780030784 @default.
- W244559346 cites W1967134059 @default.
- W244559346 cites W1979731094 @default.
- W244559346 cites W1981432540 @default.
- W244559346 cites W1984783889 @default.
- W244559346 cites W1989107717 @default.
- W244559346 cites W1990453950 @default.
- W244559346 cites W1992102272 @default.
- W244559346 cites W1994682108 @default.
- W244559346 cites W1996282211 @default.
- W244559346 cites W2005421819 @default.
- W244559346 cites W2012925826 @default.
- W244559346 cites W2016299826 @default.
- W244559346 cites W2019226819 @default.
- W244559346 cites W2021169308 @default.
- W244559346 cites W2022948175 @default.
- W244559346 cites W2025361601 @default.
- W244559346 cites W2032148614 @default.
- W244559346 cites W2035333716 @default.
- W244559346 cites W2036474156 @default.
- W244559346 cites W2046650600 @default.
- W244559346 cites W2052876262 @default.
- W244559346 cites W2058193759 @default.
- W244559346 cites W2067790439 @default.
- W244559346 cites W2068768225 @default.
- W244559346 cites W2070758851 @default.
- W244559346 cites W2072996016 @default.
- W244559346 cites W2075476726 @default.
- W244559346 cites W2081843568 @default.
- W244559346 cites W2084369308 @default.
- W244559346 cites W2087327203 @default.
- W244559346 cites W2092454947 @default.
- W244559346 cites W2095928156 @default.
- W244559346 cites W2097301400 @default.
- W244559346 cites W2097818938 @default.
- W244559346 cites W2103441770 @default.
- W244559346 cites W2104560884 @default.
- W244559346 cites W2108234281 @default.
- W244559346 cites W2112261980 @default.
- W244559346 cites W2112927445 @default.
- W244559346 cites W2116142734 @default.
- W244559346 cites W2116495476 @default.
- W244559346 cites W2118215527 @default.
- W244559346 cites W2118380724 @default.
- W244559346 cites W2119148587 @default.
- W244559346 cites W2123849507 @default.
- W244559346 cites W2124916474 @default.
- W244559346 cites W2126308420 @default.
- W244559346 cites W2130063710 @default.
- W244559346 cites W2141336798 @default.
- W244559346 cites W2141924403 @default.
- W244559346 cites W2169812063 @default.
- W244559346 cites W2170208356 @default.
- W244559346 cites W2171800666 @default.
- W244559346 doi "https://doi.org/10.1371/journal.pone.0127197" @default.
- W244559346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4433339" @default.
- W244559346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25978460" @default.
- W244559346 hasPublicationYear "2015" @default.
- W244559346 type Work @default.
- W244559346 sameAs 244559346 @default.
- W244559346 citedByCount "21" @default.
- W244559346 countsByYear W2445593462016 @default.
- W244559346 countsByYear W2445593462017 @default.
- W244559346 countsByYear W2445593462018 @default.
- W244559346 countsByYear W2445593462019 @default.
- W244559346 countsByYear W2445593462020 @default.
- W244559346 countsByYear W2445593462021 @default.
- W244559346 countsByYear W2445593462022 @default.
- W244559346 crossrefType "journal-article" @default.
- W244559346 hasAuthorship W244559346A5001042153 @default.
- W244559346 hasAuthorship W244559346A5004700592 @default.
- W244559346 hasAuthorship W244559346A5016112782 @default.
- W244559346 hasAuthorship W244559346A5022775273 @default.
- W244559346 hasAuthorship W244559346A5030469168 @default.
- W244559346 hasAuthorship W244559346A5036776546 @default.
- W244559346 hasAuthorship W244559346A5047403424 @default.
- W244559346 hasAuthorship W244559346A5048640463 @default.
- W244559346 hasAuthorship W244559346A5056381274 @default.
- W244559346 hasAuthorship W244559346A5058856297 @default.