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- W244957852 abstract "Limited chemical brominination of poly(r(C-G)) results in partial modification of guanine C8 and cytosine C5 producing a mixture of A and Z RNA forms in 110 mM NaCl buffer at 37/sup 0/C. /sup 1/H NMR of Br-poly(r(C-G)) shows a 1:1 mixture of A and Z RNAs. Nuclear Overhauser effect (NOE) experiments permit complete assignments of GH8, CH6, CH5, GH1' and CH1 resonances in both the A and Z forms. Distance estimates obtained from GH8 to GH1' NOEs demonstrate that even unbrominated guanine residues in these polynucleotides undergo a transition to the syn conformation (Z form). The Z form of Br-poly(r(C-G)) in 110 mM NaCl has a guanine Raman scattering band at 643 cm/sup -1/ in agreement with the band in the Z form of poly(r(C-G)) stabilized by 6 M NaClO/sub 4/. In A RNA the band is at 671 cm/sup -1/. The corresponding shift in DNA is from 682 cm/sup -1/ (B DNA) to 625 cm/sup -1/ (Z DNA). This suggests different glycosidic torsion angles in Z RNA and Z DNA. Inoculating rabbits with Br-poly(r(C-G)) produces polyclonal antibodies specific for the Z forms of RNA and DNA (i.e., poly(d(br/sup 5/C-G)) or poly(d(io/sup 5/C-G)) as judged by radioimmunoassay in 100 mMmore » NaCl buffers. Phosphate buffer or certain high ionic strength conditions affect the recognition of Z RNA and Z DNA by anti-Z RNA or anti-Z DNA IgGs suggesting that one determinant recognized by these antibodies is the zig-zag phosphodiester backbone.« less" @default.
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- W244957852 date "1986-05-01" @default.
- W244957852 modified "2023-09-28" @default.
- W244957852 title "Spectroscopic and immunochemical characterization of left-handed Z RNA under physiological conditions" @default.
- W244957852 hasPublicationYear "1986" @default.
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