Matches in SemOpenAlex for { <https://semopenalex.org/work/W245092126> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W245092126 abstract "Author(s): Dixon Salazar, Tracy Jean | Abstract: Major Histocompatibility Complex Class I (MHCI) proteins were first identified in the immune system but are also expressed in neurons and play a role in normal brain development and plasticity. However little is known about how, on a molecular level, MHCI modifies neuronal structure and function. Here we show that MHCI proteins interact with neuronal insulin receptors (IR) and are critical for their signaling. Dendritically expressed MHCI is closely apposed to axonally expressed IR in many brain regions, including hippocampus, and MHCI co- immunoprecipitates with IR from mouse hippocampal lysates. Unexpectedly, genetic reduction of cell surface MHCI in either [beta]2m-/-TAP-/- or Kb-/-Db-/- mice selectively alters antibody binding to an intracellular domain of the β-subunit of IR, which contains key tyrosine residues that are autophosphorylated following ligand binding. This loss of antibody binding can be rescued by co-culturing [beta]2m-/-TAP-/- neurons with wild-type neurons, suggesting MHCI and IR can interact in trans. Furthermore, [beta]2m-/-TAP-/- mice show an increase in basal tyrosine phosphorylation of IR. This increase in basal activation of IR correlates with an increase in synapse density in MHCI-deficient animals specifically in regions where IR are expressed. Together our results demonstrate that endogenous MHCI is a novel regulator of neuronal IR function and synapse number, and suggest that MHCI modifies a key c-terminal signaling domain of IR in neurons" @default.
- W245092126 created "2016-06-24" @default.
- W245092126 creator A5024437137 @default.
- W245092126 creator A5025934030 @default.
- W245092126 date "2009-01-01" @default.
- W245092126 modified "2023-09-26" @default.
- W245092126 title "Major histocompatibility complex class I is a negative regulator of neuronal insulin receptor signaling and hippocampal synapse number" @default.
- W245092126 hasPublicationYear "2009" @default.
- W245092126 type Work @default.
- W245092126 sameAs 245092126 @default.
- W245092126 citedByCount "0" @default.
- W245092126 crossrefType "journal-article" @default.
- W245092126 hasAuthorship W245092126A5024437137 @default.
- W245092126 hasAuthorship W245092126A5025934030 @default.
- W245092126 hasConcept C104317684 @default.
- W245092126 hasConcept C11960822 @default.
- W245092126 hasConcept C127445978 @default.
- W245092126 hasConcept C148762608 @default.
- W245092126 hasConcept C169760540 @default.
- W245092126 hasConcept C170493617 @default.
- W245092126 hasConcept C170627219 @default.
- W245092126 hasConcept C203014093 @default.
- W245092126 hasConcept C207936829 @default.
- W245092126 hasConcept C2777553839 @default.
- W245092126 hasConcept C2781161787 @default.
- W245092126 hasConcept C55493867 @default.
- W245092126 hasConcept C6929976 @default.
- W245092126 hasConcept C86803240 @default.
- W245092126 hasConcept C8891405 @default.
- W245092126 hasConcept C95444343 @default.
- W245092126 hasConceptScore W245092126C104317684 @default.
- W245092126 hasConceptScore W245092126C11960822 @default.
- W245092126 hasConceptScore W245092126C127445978 @default.
- W245092126 hasConceptScore W245092126C148762608 @default.
- W245092126 hasConceptScore W245092126C169760540 @default.
- W245092126 hasConceptScore W245092126C170493617 @default.
- W245092126 hasConceptScore W245092126C170627219 @default.
- W245092126 hasConceptScore W245092126C203014093 @default.
- W245092126 hasConceptScore W245092126C207936829 @default.
- W245092126 hasConceptScore W245092126C2777553839 @default.
- W245092126 hasConceptScore W245092126C2781161787 @default.
- W245092126 hasConceptScore W245092126C55493867 @default.
- W245092126 hasConceptScore W245092126C6929976 @default.
- W245092126 hasConceptScore W245092126C86803240 @default.
- W245092126 hasConceptScore W245092126C8891405 @default.
- W245092126 hasConceptScore W245092126C95444343 @default.
- W245092126 hasLocation W2450921261 @default.
- W245092126 hasOpenAccess W245092126 @default.
- W245092126 hasPrimaryLocation W2450921261 @default.
- W245092126 hasRelatedWork W1967404650 @default.
- W245092126 hasRelatedWork W1967455555 @default.
- W245092126 hasRelatedWork W2003017196 @default.
- W245092126 hasRelatedWork W2012082094 @default.
- W245092126 hasRelatedWork W2019184486 @default.
- W245092126 hasRelatedWork W2039510759 @default.
- W245092126 hasRelatedWork W2078302016 @default.
- W245092126 hasRelatedWork W2109281837 @default.
- W245092126 hasRelatedWork W2123408996 @default.
- W245092126 hasRelatedWork W2138320069 @default.
- W245092126 hasRelatedWork W2342154891 @default.
- W245092126 hasRelatedWork W2467328988 @default.
- W245092126 hasRelatedWork W2521843398 @default.
- W245092126 hasRelatedWork W2562584466 @default.
- W245092126 hasRelatedWork W2625597160 @default.
- W245092126 hasRelatedWork W2969945887 @default.
- W245092126 hasRelatedWork W2973578148 @default.
- W245092126 hasRelatedWork W3044033680 @default.
- W245092126 hasRelatedWork W3103041540 @default.
- W245092126 hasRelatedWork W3110718769 @default.
- W245092126 isParatext "false" @default.
- W245092126 isRetracted "false" @default.
- W245092126 magId "245092126" @default.
- W245092126 workType "article" @default.