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- W245277275 abstract "During the last year there have been several reports from a number of laboratories showing that L-asparaginase has profound immunosuppressive effects in animals (1–15). Until recently, this enzyme was generally considered to have specific anti-leukemic effects (16–18). However, it is now evident that asparaginase may be a useful immunosuppressive agent, inhibiting antibody formation (6,7,9–11,13,14), lymphocyte transformation (1–3), the graft-vs.-host reaction (8) and graft rejection (4,12,13,15). We have studied the effects of L-asparaginase derived from Escherichia coli on the antibody plaque response of mice to sheep erythrocytes and E. coli, as well as its effects on the allograft rejection phenomenon." @default.
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- W245277275 date "1971-01-01" @default.
- W245277275 modified "2023-09-27" @default.
- W245277275 title "Immunosuppression by L-Asparaginase" @default.
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- W245277275 doi "https://doi.org/10.1007/978-1-4615-9011-8_81" @default.
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