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• W24548532 abstract "Mitochondrial dysfunction has been implicated in the early pathogenesis of Type 2 Diabetes. The uncoupling proteins 2 and 3 are mitochondrial proteins found in man that have been implicated in protecting mammals from the effects of over-nutrition. Examination of the effect of genetic variation in the UCP2-UCP3 genetic cluster has so far been inconclusive. The aim of this thesis was to examine, using a genetic strategy, the hypothesis that the role of the uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes is via modification of oxidative stress.In a prospective study of nearly 3000 men the risk of type 2 diabetes at 10 years was increased for both the UCP2-866AA (1.94 [1.18-3.19]: p=0.009) and the UCP3-55TT (2.06 [1.06-3.99]: p=0.03) homozygotes. This increased risk was not explained by the association with any measured conventional risk factors. Paradoxically, in a Europe-wide cross-sectional study of 598 subjects the UCP2-866A variant was associated with lower waist-hip ratio (GX v AA,1.00 [0.06] v 0.98 [0.07]; p=0.003), although also associated with lower insulin secretion (42.6 [24.6] v 35.6 [18.6]; p=0.03). The UCP3 variant was not significantly associated with any metabolic trait.The significant heritability of plasma markers of oxidative stress (TAS 0.54, TOAS 0.49) suggests anti-oxidant function is a plausible mechanism to determine Type 2 Diabetes risk. The predictors of anti-oxidant stress in a family study were examined, as was the impact of UCP2-UCP3 gene cluster variation. Genetic variation in the UCP2-UCP3 was found to increase the risk of the Type 2 diabetes. While UCP2 may modify insulin secretion directly, the mechanism of action for UCP3 is likely to involve novel risk factors for Type 2 Diabetes such as modification of mitochondrial oxidative stress. Finally, the development of a human model is described to examine genetic influences on oxidative stress burden using a meal rich in used cooking oil." @default.
• W24548532 created "2016-06-24" @default.
• W24548532 creator A5008349369 @default.
• W24548532 date "2008-01-01" @default.
• W24548532 modified "2023-09-28" @default.
• W24548532 title "The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes." @default.
• W24548532 cites W1485161311 @default.
• W24548532 cites W1489408430 @default.
• W24548532 cites W1493509581 @default.
• W24548532 cites W1503600099 @default.
• W24548532 cites W1522183720 @default.
• W24548532 cites W1522893416 @default.
• W24548532 cites W1525444530 @default.
• W24548532 cites W1529592271 @default.
• W24548532 cites W1539843762 @default.
• W24548532 cites W1546541679 @default.
• W24548532 cites W1550000221 @default.
• W24548532 cites W1559903407 @default.
• W24548532 cites W156498367 @default.
• W24548532 cites W1567614586 @default.
• W24548532 cites W1568960993 @default.
• W24548532 cites W1572718689 @default.
• W24548532 cites W1580646470 @default.
• W24548532 cites W1582691127 @default.
• W24548532 cites W1588954369 @default.
• W24548532 cites W1590457525 @default.
• W24548532 cites W1592900851 @default.
• W24548532 cites W1594144439 @default.
• W24548532 cites W1594539479 @default.
• W24548532 cites W1594856996 @default.
• W24548532 cites W1598662907 @default.
• W24548532 cites W1631337323 @default.
• W24548532 cites W1759706356 @default.
• W24548532 cites W1773423156 @default.
• W24548532 cites W1776131825 @default.
• W24548532 cites W1837652736 @default.
• W24548532 cites W1847256235 @default.
• W24548532 cites W1860005470 @default.
• W24548532 cites W1866908740 @default.
• W24548532 cites W1891967301 @default.
• W24548532 cites W1900866157 @default.
• W24548532 cites W1904188511 @default.
• W24548532 cites W1905838994 @default.
• W24548532 cites W1919789442 @default.
• W24548532 cites W1938202327 @default.
• W24548532 cites W1942610538 @default.
• W24548532 cites W1959338601 @default.
• W24548532 cites W1959438396 @default.
• W24548532 cites W1963820380 @default.
• W24548532 cites W1963820921 @default.
• W24548532 cites W1963825223 @default.
• W24548532 cites W1964172387 @default.
• W24548532 cites W1964364456 @default.
• W24548532 cites W1965100476 @default.
• W24548532 cites W1965141016 @default.
• W24548532 cites W1965210942 @default.
• W24548532 cites W1965405931 @default.
• W24548532 cites W1966116228 @default.
• W24548532 cites W1966526637 @default.
• W24548532 cites W1966621383 @default.
• W24548532 cites W1967315314 @default.
• W24548532 cites W1968168087 @default.
• W24548532 cites W1968314533 @default.
• W24548532 cites W1968388017 @default.
• W24548532 cites W1970389856 @default.
• W24548532 cites W1970452249 @default.
• W24548532 cites W1970631259 @default.
• W24548532 cites W1970844785 @default.
• W24548532 cites W1970997604 @default.
• W24548532 cites W1971004115 @default.
• W24548532 cites W1971082641 @default.
• W24548532 cites W1971229175 @default.
• W24548532 cites W1971452427 @default.
• W24548532 cites W1971712685 @default.
• W24548532 cites W1972168039 @default.
• W24548532 cites W1972836378 @default.
• W24548532 cites W1973842058 @default.
• W24548532 cites W1973957785 @default.
• W24548532 cites W1974629752 @default.
• W24548532 cites W1975334244 @default.
• W24548532 cites W1975419167 @default.
• W24548532 cites W1975447813 @default.
• W24548532 cites W1975951926 @default.
• W24548532 cites W1976407135 @default.
• W24548532 cites W1976535279 @default.
• W24548532 cites W1976616659 @default.
• W24548532 cites W1976748679 @default.
• W24548532 cites W1977284247 @default.
• W24548532 cites W1977464568 @default.
• W24548532 cites W1977835981 @default.
• W24548532 cites W1977913875 @default.
• W24548532 cites W1978641757 @default.
• W24548532 cites W1979557617 @default.
• W24548532 cites W1981870124 @default.
• W24548532 cites W1982245022 @default.
• W24548532 cites W1983213612 @default.
• W24548532 cites W1983729336 @default.
• W24548532 cites W1983894726 @default.
• W24548532 cites W1984142219 @default.
• W24548532 cites W1984948906 @default.

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