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- W24580018 abstract "This study evaluated the relative importance of D 3 receptor antagonism in the discriminative stimulus effects of the putative D 3 receptor antagonist PNU-99194A. Eight male Sprague–Dawley rats were trained to discriminate PNU-99194A (10 mg/kg sc) from vehicle in a two-choice drug discrimination procedure under a FR 20 schedule of food reinforcement. The selective D 3 antagonists PD 152255 and S14297 were examined for stimulus generalization. The D 2 antagonist haloperidol and the D 2 /D 3 receptor agonist (+)-7-OH-DPAT were also assessed for antagonism of PNU-99194A discrimination. PD 152255 (1.0–3.0 mg/kg) engendered no generalization to PNU-99194A. Due to its markedly rate-suppressive effects, PD 152255 could not be tested at higher doses. S-14297 produced partial substitution (66%) for PNU-99194A at both 3.0 and 8.0 mg/kg. Neither haloperidol nor (+)-7-OH-DPAT blocked the discrimination of PNU-99194A and, surprisingly, actually appeared to potentiate its effects. These data, along with other recent findings, suggest that the discriminative stimulus effects of PNU-99194A appear to involve complex pharmacological actions and are not solely mediated by D 3 receptor antagonism." @default.
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- W24580018 date "2002-11-01" @default.
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- W24580018 title "Reevaluation of PNU-99194A discriminative stimulus effects" @default.
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- W24580018 doi "https://doi.org/10.1016/s0091-3057(02)00882-1" @default.
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