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- W245846286 abstract "Abstract : British anti-Lewisite (BAL) (2,3-dimercapto-1-propanol) is a potential therapeutic compound against the effects of cutaneous sulfur mustard, and an method for its determination in plasma has been developed. BAL and the internal standard (IS) ethane dithiol were removed from plasma samples through solid phase extraction, then reacted with 1-pentafluoropropionylimidazole (PFPI), forming stable pentafluoropropionyl derivates that are sensitive to gas chromatography/mass spectroscopy (GC/MS) analysis. Examining concentrations versus peak area ratios of BAL and IS derivatives demonstrated the method to be linear from 0.48 to 124 ng/ml in plasma with acceptable accuracy and precision. This method has proven to be both a reliable and sensitive means to determine BAL in plasma." @default.
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- W245846286 date "2005-10-01" @default.
- W245846286 modified "2023-09-26" @default.
- W245846286 title "A Method to Determine British Anti-Lewisite in Plasma Utilizing Gas Chromatography/Mass Spectrometry" @default.
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