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• W24596014 abstract "References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Abstract Skin aging involves progressive degenerative change, such as gradual dryness, thinning, fragility, atrophy, wrinkling, a progressive increase in extensibility, and a reduction in elasticity, becoming more susceptible to injury. The average woman spends about a third of her life after the onset of menopause. Estrogen replacement therapy (ERT) has been regularly prescribed, which reduces symptoms associated with menopause. Much data exists regarding estrogen’s role in aging skin and evidence of ERTon ameliorating postmenopausal aging, which have been analyzed with multiple perspectives. Numerous studies reported increases in collagen skin thickness and skin elasticity, thus reducing wrinkling, and increases in skin moisture after ERT. Estrogen also affects wound healing and scarring, but much remains to be elucidated regarding the mechanisms by which estrogen acts. There may be limitations on the benefits of ERT, though, depending on the type of skin damage accumulated. A limited number of studies contradict these benefits of ERT. Due to a lack of standardized methods, not all studies are comparable, and the power of each study differs. Overall, it seems clear that there is a role of the therapeutic use of estrogen on skin. Selective estrogen receptor modulators (SERMS) are a viable option that should be further explored. Increased research should be directed at the clinical pharmacology of estrogen and medical prescription, such as C. Phuong (*) • H.I. Maibach Department of Dermatology, University of California San Francisco, San Francisco, CA, USA e-mail: cphuong49@gmail.com; maibachh@derm. ucsf.edu" @default.
• W24596014 created "2016-06-24" @default.
• W24596014 creator A5071733992 @default.
• W24596014 date "2012-02-03" @default.
• W24596014 modified "2023-09-24" @default.
• W24596014 title "Biological Effects of Estrogen on Skin" @default.
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• W24596014 doi "https://doi.org/10.1007/springerreference_168395" @default.
• W24596014 hasPublicationYear "2012" @default.
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