Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460135013> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2460135013 endingPage "160" @default.
- W2460135013 startingPage "155" @default.
- W2460135013 abstract "9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG), a nucleoside analogue, inhibits the replication of human and murine cytomegalovirus (MCMV) in cell culture. We studied the effects of treatment with DHPG on acute MCMV infection in mice and assessed the impact of drug therapy on the eventual development of latent viral infection. In virus-susceptible Balb/c mice, DHPG treatment limited dissemination of virus infection and prevented death. In sublethal infection of both Balb/c and virus-resistant C3H/St mice, DHPG prevented recovery of infectious virus from visceral organs, including the spleen. Despite these effects of drug treatment on virus replication during acute infection, latent MCMV could be reactivated in vivo by immunosuppression and in vitro by spleen explantation in virtually all mice. These results indicate that successful treatment of MCMV infection and marked suppression of viral replication do not prevent establishment of viral latency." @default.
- W2460135013 created "2016-07-22" @default.
- W2460135013 creator A5022416753 @default.
- W2460135013 creator A5054606492 @default.
- W2460135013 creator A5089965593 @default.
- W2460135013 date "1986-08-01" @default.
- W2460135013 modified "2023-09-23" @default.
- W2460135013 title "Successful treatment of murine cytomegalovirus disease does not prevent latent virus infection." @default.
- W2460135013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3016127" @default.
- W2460135013 hasPublicationYear "1986" @default.
- W2460135013 type Work @default.
- W2460135013 sameAs 2460135013 @default.
- W2460135013 citedByCount "2" @default.
- W2460135013 crossrefType "journal-article" @default.
- W2460135013 hasAuthorship W2460135013A5022416753 @default.
- W2460135013 hasAuthorship W2460135013A5054606492 @default.
- W2460135013 hasAuthorship W2460135013A5089965593 @default.
- W2460135013 hasConcept C140704245 @default.
- W2460135013 hasConcept C150903083 @default.
- W2460135013 hasConcept C159047783 @default.
- W2460135013 hasConcept C203014093 @default.
- W2460135013 hasConcept C207001950 @default.
- W2460135013 hasConcept C2522874641 @default.
- W2460135013 hasConcept C2776409557 @default.
- W2460135013 hasConcept C2777732132 @default.
- W2460135013 hasConcept C2777965375 @default.
- W2460135013 hasConcept C2778852064 @default.
- W2460135013 hasConcept C2779820661 @default.
- W2460135013 hasConcept C2780252810 @default.
- W2460135013 hasConcept C2780727368 @default.
- W2460135013 hasConcept C2780931953 @default.
- W2460135013 hasConcept C2910737674 @default.
- W2460135013 hasConcept C86803240 @default.
- W2460135013 hasConceptScore W2460135013C140704245 @default.
- W2460135013 hasConceptScore W2460135013C150903083 @default.
- W2460135013 hasConceptScore W2460135013C159047783 @default.
- W2460135013 hasConceptScore W2460135013C203014093 @default.
- W2460135013 hasConceptScore W2460135013C207001950 @default.
- W2460135013 hasConceptScore W2460135013C2522874641 @default.
- W2460135013 hasConceptScore W2460135013C2776409557 @default.
- W2460135013 hasConceptScore W2460135013C2777732132 @default.
- W2460135013 hasConceptScore W2460135013C2777965375 @default.
- W2460135013 hasConceptScore W2460135013C2778852064 @default.
- W2460135013 hasConceptScore W2460135013C2779820661 @default.
- W2460135013 hasConceptScore W2460135013C2780252810 @default.
- W2460135013 hasConceptScore W2460135013C2780727368 @default.
- W2460135013 hasConceptScore W2460135013C2780931953 @default.
- W2460135013 hasConceptScore W2460135013C2910737674 @default.
- W2460135013 hasConceptScore W2460135013C86803240 @default.
- W2460135013 hasIssue "2" @default.
- W2460135013 hasLocation W24601350131 @default.
- W2460135013 hasOpenAccess W2460135013 @default.
- W2460135013 hasPrimaryLocation W24601350131 @default.
- W2460135013 hasRelatedWork W1964658858 @default.
- W2460135013 hasRelatedWork W1969185086 @default.
- W2460135013 hasRelatedWork W2005156515 @default.
- W2460135013 hasRelatedWork W2010440994 @default.
- W2460135013 hasRelatedWork W2015417561 @default.
- W2460135013 hasRelatedWork W2019373380 @default.
- W2460135013 hasRelatedWork W2061941938 @default.
- W2460135013 hasRelatedWork W2064182008 @default.
- W2460135013 hasRelatedWork W2078653423 @default.
- W2460135013 hasRelatedWork W2100942927 @default.
- W2460135013 hasRelatedWork W2115042572 @default.
- W2460135013 hasRelatedWork W2120594273 @default.
- W2460135013 hasRelatedWork W2135120351 @default.
- W2460135013 hasRelatedWork W2154028161 @default.
- W2460135013 hasRelatedWork W2160310902 @default.
- W2460135013 hasRelatedWork W2175122451 @default.
- W2460135013 hasRelatedWork W2392178457 @default.
- W2460135013 hasRelatedWork W2417442122 @default.
- W2460135013 hasRelatedWork W658741028 @default.
- W2460135013 hasRelatedWork W2554259234 @default.
- W2460135013 hasVolume "108" @default.
- W2460135013 isParatext "false" @default.
- W2460135013 isRetracted "false" @default.
- W2460135013 magId "2460135013" @default.
- W2460135013 workType "article" @default.