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- W2460144533 endingPage "76" @default.
- W2460144533 startingPage "68" @default.
- W2460144533 abstract "The advent of second generation chimeric antigen receptors and the CD19 paradigm have ushered a new therapeutic modality in oncology. In contrast to earlier forms of adoptive cell therapy, which were based on the isolation and expansion of naturally occurring T cells, CAR therapy is based on the design and manufacture of engineered T cells with optimized properties. A new armamentarium, comprising not only CARs but also chimeric costimulatory receptors, chimeric cytokine receptors, inhibitory receptors and synthetic Notch receptors, expressed in naïve, central memory or stem cell-like memory T cells, is being developed for clinical use in a wide range of cancers. Immunological principles are thus finding a new purpose thanks to advances in genetic engineering, synthetic biology and cell manufacturing sciences." @default.
- W2460144533 created "2016-07-22" @default.
- W2460144533 creator A5059625599 @default.
- W2460144533 date "2016-08-01" @default.
- W2460144533 modified "2023-10-01" @default.
- W2460144533 title "Chimeric antigen receptors: driving immunology towards synthetic biology" @default.
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