Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460237831> ?p ?o ?g. }
- W2460237831 abstract "The estrogen receptor (ER) inhibitor tamoxifen reduces breast cancer mortality by 31 % and has served as the standard treatment for ER-positive breast cancers for decades. However, 50 % of advanced ER-positive cancers display de novo resistance to tamoxifen, and acquired resistance evolves in 40 % of patients who initially respond. Mechanisms underlying resistance development remain poorly understood and new therapeutic opportunities are urgently needed. Here, we report the generation and characterization of seven tamoxifen-resistant breast cancer cell lines from four parental strains.Using high throughput drug sensitivity and resistance testing (DSRT) with 279 approved and investigational oncology drugs, exome-sequencing and network analysis, we for the first time, systematically determine the drug response profiles specific to tamoxifen resistance.We discovered emerging vulnerabilities towards specific drugs, such as ERK1/2-, proteasome- and BCL-family inhibitors as the cells became tamoxifen-resistant. Co-resistance to other drugs such as the survivin inhibitor YM155 and the chemotherapeutic agent paclitaxel also occurred.This study indicates that multiple molecular mechanisms dictate endocrine resistance, resulting in unexpected vulnerabilities to initially ineffective drugs, as well as in emerging co-resistances. Thus, combatting drug-resistant tumors will require patient-tailored strategies in order to identify new drug vulnerabilities, and to understand the associated co-resistance patterns." @default.
- W2460237831 created "2016-07-22" @default.
- W2460237831 creator A5016681267 @default.
- W2460237831 creator A5023554856 @default.
- W2460237831 creator A5038194713 @default.
- W2460237831 creator A5050670008 @default.
- W2460237831 creator A5059976362 @default.
- W2460237831 creator A5061666924 @default.
- W2460237831 creator A5067244168 @default.
- W2460237831 creator A5085642802 @default.
- W2460237831 creator A5089248994 @default.
- W2460237831 date "2016-07-04" @default.
- W2460237831 modified "2023-10-15" @default.
- W2460237831 title "Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer" @default.
- W2460237831 cites W1502739652 @default.
- W2460237831 cites W1544708502 @default.
- W2460237831 cites W1569513357 @default.
- W2460237831 cites W1656816575 @default.
- W2460237831 cites W1889928106 @default.
- W2460237831 cites W1944448503 @default.
- W2460237831 cites W1967099832 @default.
- W2460237831 cites W1985445337 @default.
- W2460237831 cites W1990841870 @default.
- W2460237831 cites W1996711635 @default.
- W2460237831 cites W1997006452 @default.
- W2460237831 cites W2002783575 @default.
- W2460237831 cites W2003731962 @default.
- W2460237831 cites W2013956549 @default.
- W2460237831 cites W2017021495 @default.
- W2460237831 cites W2021145743 @default.
- W2460237831 cites W2022770843 @default.
- W2460237831 cites W2023384375 @default.
- W2460237831 cites W2025005089 @default.
- W2460237831 cites W2027442209 @default.
- W2460237831 cites W2034008568 @default.
- W2460237831 cites W2035421116 @default.
- W2460237831 cites W2035585923 @default.
- W2460237831 cites W2036469777 @default.
- W2460237831 cites W2043065181 @default.
- W2460237831 cites W2047464860 @default.
- W2460237831 cites W2050831491 @default.
- W2460237831 cites W2057000572 @default.
- W2460237831 cites W2073367400 @default.
- W2460237831 cites W2078902726 @default.
- W2460237831 cites W2080174206 @default.
- W2460237831 cites W2084917180 @default.
- W2460237831 cites W2089595068 @default.
- W2460237831 cites W2090363153 @default.
- W2460237831 cites W2096774816 @default.
- W2460237831 cites W2098407557 @default.
- W2460237831 cites W2100506877 @default.
- W2460237831 cites W2105095453 @default.
- W2460237831 cites W2106578986 @default.
- W2460237831 cites W2107311126 @default.
- W2460237831 cites W2109309944 @default.
- W2460237831 cites W2109388713 @default.
- W2460237831 cites W2114941442 @default.
- W2460237831 cites W2115517051 @default.
- W2460237831 cites W2119274522 @default.
- W2460237831 cites W2120593345 @default.
- W2460237831 cites W2122769974 @default.
- W2460237831 cites W2124812632 @default.
- W2460237831 cites W2128605357 @default.
- W2460237831 cites W2129087581 @default.
- W2460237831 cites W2129352379 @default.
- W2460237831 cites W2138911924 @default.
- W2460237831 cites W2144334805 @default.
- W2460237831 cites W2146383973 @default.
- W2460237831 cites W2153056550 @default.
- W2460237831 cites W2155943701 @default.
- W2460237831 cites W2157392528 @default.
- W2460237831 cites W2157650470 @default.
- W2460237831 cites W2157852151 @default.
- W2460237831 cites W2159363850 @default.
- W2460237831 cites W2159415114 @default.
- W2460237831 cites W2161365514 @default.
- W2460237831 cites W2162143298 @default.
- W2460237831 cites W2165537229 @default.
- W2460237831 cites W2167703924 @default.
- W2460237831 cites W2171642372 @default.
- W2460237831 cites W2332131832 @default.
- W2460237831 cites W4238991694 @default.
- W2460237831 doi "https://doi.org/10.1186/s12885-016-2452-5" @default.
- W2460237831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4932681" @default.
- W2460237831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27378269" @default.
- W2460237831 hasPublicationYear "2016" @default.
- W2460237831 type Work @default.
- W2460237831 sameAs 2460237831 @default.
- W2460237831 citedByCount "10" @default.
- W2460237831 countsByYear W24602378312018 @default.
- W2460237831 countsByYear W24602378312019 @default.
- W2460237831 countsByYear W24602378312020 @default.
- W2460237831 countsByYear W24602378312021 @default.
- W2460237831 countsByYear W24602378312023 @default.
- W2460237831 crossrefType "journal-article" @default.
- W2460237831 hasAuthorship W2460237831A5016681267 @default.
- W2460237831 hasAuthorship W2460237831A5023554856 @default.
- W2460237831 hasAuthorship W2460237831A5038194713 @default.
- W2460237831 hasAuthorship W2460237831A5050670008 @default.
- W2460237831 hasAuthorship W2460237831A5059976362 @default.