FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460344240> ?p ?o ?g. }

• W2460344240 endingPage "4048" @default.
• W2460344240 startingPage "4042" @default.
• W2460344240 abstract "Intraoperative analysis of sentinel lymph nodes would enhance the care of early-stage oral squamous cell carcinoma (OSCC). We determined the frequency and extent of cytokeratin 19 (CK19) expression in OSCC primary tumours and surrounding tissues to explore the feasibility of a clinic-ready intraoperative diagnostic test (one step nucleic acid amplification-OSNA, sysmex).Two cohorts were assembled: cohort 1, OSCC with stage and site that closely match cases suitable for sentinel lymph node biopsy (SLNB); cohort 2, HNSCC with sufficient fresh tumour tissue available for the OSNA assay (>50 mg). CK19 assays included qRT-PCR, RNA in situ hybridisation (ISH), and immunohistochemistry (IHC), as well as OSNA.CK19 mRNA expression was detected with variable sensitivity, depending on method, in 60-80% of primary OSCC tumours, while protein expression was observed in only 50% of tumours. Discordance between different techniques indicated that OSNA was more sensitive than qRT-PCR or RNA-ISH, which in turn were more sensitive than IHC. OSNA results showed CK19 expression in 80% of primary cases, so if used for diagnosis of lymph node metastasis would lead to a false-negative result in 20% of patients with cervical lymph node metastases.OSNA in its current form is not suitable for use in OSCC SLNB due to inadequate expression of the CK19 target in all case. However, the same assay technology would likely be very promising if applied using a more ubiquitous squamous epithelial target." @default.
• W2460344240 created "2016-07-22" @default.
• W2460344240 creator A5004687651 @default.
• W2460344240 creator A5011434167 @default.
• W2460344240 creator A5020871326 @default.
• W2460344240 creator A5026367879 @default.
• W2460344240 creator A5033000612 @default.
• W2460344240 creator A5033957754 @default.
• W2460344240 creator A5044660787 @default.
• W2460344240 creator A5045900390 @default.
• W2460344240 creator A5049247909 @default.
• W2460344240 creator A5059181867 @default.
• W2460344240 creator A5061371539 @default.
• W2460344240 creator A5070515910 @default.
• W2460344240 creator A5075681821 @default.
• W2460344240 creator A5085910405 @default.
• W2460344240 date "2016-07-08" @default.
• W2460344240 modified "2023-09-27" @default.
• W2460344240 title "Intraoperative Sentinel Lymph Node Evaluation: Implications of Cytokeratin 19 Expression for the Adoption of OSNA in Oral Squamous Cell Carcinoma" @default.
• W2460344240 cites W1845660782 @default.
• W2460344240 cites W1858202133 @default.
• W2460344240 cites W1971629617 @default.
• W2460344240 cites W1974312067 @default.
• W2460344240 cites W1989674333 @default.
• W2460344240 cites W2010911145 @default.
• W2460344240 cites W2019491795 @default.
• W2460344240 cites W2021729718 @default.
• W2460344240 cites W2035639435 @default.
• W2460344240 cites W2044837540 @default.
• W2460344240 cites W2047127733 @default.
• W2460344240 cites W2048588872 @default.
• W2460344240 cites W2054345791 @default.
• W2460344240 cites W2057243823 @default.
• W2460344240 cites W2060599323 @default.
• W2460344240 cites W2062608449 @default.
• W2460344240 cites W2076560612 @default.
• W2460344240 cites W2090329198 @default.
• W2460344240 cites W2097286819 @default.
• W2460344240 cites W2105275554 @default.
• W2460344240 cites W2106958102 @default.
• W2460344240 cites W2112506561 @default.
• W2460344240 cites W2129264768 @default.
• W2460344240 cites W2214035636 @default.
• W2460344240 cites W2283809829 @default.
• W2460344240 doi "https://doi.org/10.1245/s10434-016-5337-6" @default.
• W2460344240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5047925" @default.
• W2460344240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27393570" @default.
• W2460344240 hasPublicationYear "2016" @default.
• W2460344240 type Work @default.
• W2460344240 sameAs 2460344240 @default.
• W2460344240 citedByCount "9" @default.
• W2460344240 countsByYear W24603442402017 @default.
• W2460344240 countsByYear W24603442402018 @default.
• W2460344240 countsByYear W24603442402019 @default.
• W2460344240 countsByYear W24603442402020 @default.
• W2460344240 countsByYear W24603442402021 @default.
• W2460344240 countsByYear W24603442402022 @default.
• W2460344240 crossrefType "journal-article" @default.
• W2460344240 hasAuthorship W2460344240A5004687651 @default.
• W2460344240 hasAuthorship W2460344240A5011434167 @default.
• W2460344240 hasAuthorship W2460344240A5020871326 @default.
• W2460344240 hasAuthorship W2460344240A5026367879 @default.
• W2460344240 hasAuthorship W2460344240A5033000612 @default.
• W2460344240 hasAuthorship W2460344240A5033957754 @default.
• W2460344240 hasAuthorship W2460344240A5044660787 @default.
• W2460344240 hasAuthorship W2460344240A5045900390 @default.
• W2460344240 hasAuthorship W2460344240A5049247909 @default.
• W2460344240 hasAuthorship W2460344240A5059181867 @default.
• W2460344240 hasAuthorship W2460344240A5061371539 @default.
• W2460344240 hasAuthorship W2460344240A5070515910 @default.
• W2460344240 hasAuthorship W2460344240A5075681821 @default.
• W2460344240 hasAuthorship W2460344240A5085910405 @default.
• W2460344240 hasBestOaLocation W24603442401 @default.
• W2460344240 hasConcept C121608353 @default.
• W2460344240 hasConcept C126322002 @default.
• W2460344240 hasConcept C142724271 @default.
• W2460344240 hasConcept C143998085 @default.
• W2460344240 hasConcept C146357865 @default.
• W2460344240 hasConcept C151730666 @default.
• W2460344240 hasConcept C179671157 @default.
• W2460344240 hasConcept C204232928 @default.
• W2460344240 hasConcept C2775934546 @default.
• W2460344240 hasConcept C2777546739 @default.
• W2460344240 hasConcept C2779012181 @default.
• W2460344240 hasConcept C2779720271 @default.
• W2460344240 hasConcept C2780140570 @default.
• W2460344240 hasConcept C2780212769 @default.
• W2460344240 hasConcept C2780849966 @default.
• W2460344240 hasConcept C530470458 @default.
• W2460344240 hasConcept C71924100 @default.
• W2460344240 hasConcept C86803240 @default.
• W2460344240 hasConceptScore W2460344240C121608353 @default.
• W2460344240 hasConceptScore W2460344240C126322002 @default.
• W2460344240 hasConceptScore W2460344240C142724271 @default.
• W2460344240 hasConceptScore W2460344240C143998085 @default.
• W2460344240 hasConceptScore W2460344240C146357865 @default.
• W2460344240 hasConceptScore W2460344240C151730666 @default.
• W2460344240 hasConceptScore W2460344240C179671157 @default.

• next