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• W2460363617 abstract "In this issue of Cardiovascular Research , a collection of recently published papers is made available specifically aiming to illustrate recent advances in cardiovascular protection, a topic that is prominent at the 2016 Frontiers in Cardiovascular Biology (FCVB) meeting (http://www.escardio.org/Congresses-&-Events/Upcoming-congresses/Frontiers-in-Cardiovascular-Biology/Frontiers-in-Cardiovascular-Biology).The papers are freely available online in the ‘Focus on cardiovascular protection’ virtual issue which can be accessed at bit.ly/CVR-FCVBAfter the recent disappointment of the CIRCUS trial,1 new ideas for cardioprotection during reperfusion after ischaemia are needed with strong mechanistic support and preclinical evaluation. A meta-analysis of large animal studies further underscores the need for critical evaluation of study design and preclinical data interpretation for translation,2 a principle also advanced by the editors of Cardiovascular Research .3 Novel strategies for cardioprotection need to be tested in a clinically relevant framework, as laid out in the position paper of the ESC Working Groups Cellular Biology of the Heart.4 Novel ideas are generated in mechanistic studies as well as more translational studies.Mitochondria are main actors involved in I/R injury. Inhibition of mitochondrial permeability transition pore (mPTP) opening is know to be cardioprotective; the role of UCP3 was uncovered through targeted molecular interventions5 while during I/R several activation mechanisms …" @default.
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• W2460363617 date "2016-07-08" @default.
• W2460363617 modified "2023-09-24" @default.
• W2460363617 title "Virtual issue: focus on cardiovascular protection" @default.
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• W2460363617 doi "https://doi.org/10.1093/cvr/cvw160" @default.
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