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• W2460396245 abstract "PURPOSE: Neuregulin 1 (NRG1) is involved in the regulation of glucose metabolism in rodent skeletal muscle. We hypothesized that metabolic disorders could be associated with alterations of the NRG1 signaling pathway and that chronic endurance exercise could improve NRG1 signaling in rat skeletal muscle. METHODS: Male Wistar rats were fed a high fat/high sucrose (HF/HS) diet for 16 weeks. At the end of this period, NRG1 and ErbB expression/activity were assessed in skeletal muscle of obese rat suffering from glucose intolerance induced by the HF/HS diet and compared to controls (nonobese, well-balanced diet). Then, the obese rats continued the HF/HS diet without or with endurance exercise training (5 times/week) or were switched to a well-balanced diet without or with exercise training for another 8 weeks and NRG1 and ErbB expression/activity in skeletal muscle were tested again. RESULTS: First, we found that a 16-week HF/HS diet induced obesity, but did not significantly affect the NRG1/ErbB signaling pathway in rat skeletal muscle. Conversely, after HF/HS obese rats were switched to a well-balanced diet with endurance exercise training for 8 weeks, NRG1 cleavage ratio in skeletal muscle was increased by 3-fold and ErbB4 phosphorylation by 1.7-fold compared to control animals (HF/HS diet, without intervention). This was associated with increased protein expression and phosphorylation ratio of the metalloprotease ADAM17, which is involved in NRG1 shedding. Well-balanced diet or physical exercise alone did not induce these effects, demonstrating a synergistic effect of these interventions. Similarly, in vitro stretch-induced activation of ADAM17 in rat myoblasts induced NRG1 cleavage and ErbB4 activation. CONCLUSIONS: These results showed that endurance training combined with a well-balanced diet activates the NRG1-ErbB4 pathway in skeletal muscle of obese rats. This effect, possibly through ADAM17-mediated cleavage of NRG1, might improve the cell carbohydrate metabolism in metabolic disorders. Supported by the Heart and Arteries Foundation (Fondation Coeur et Artères)." @default.
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• W2460396245 date "2015-05-01" @default.
• W2460396245 modified "2023-10-16" @default.
• W2460396245 title "Exercise Training Combined With A Well-balanced Diet Activates Nrg1 Pathway In Gastrocnemius Of Obese Rats" @default.
• W2460396245 doi "https://doi.org/10.1249/01.mss.0000477558.97412.35" @default.
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