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- W2460398187 abstract "Objective To investigate the correlation of the mRNA expression level of excision repair cross-complementing group 1 （ERCC1） gene with clinicopathological parameters and clinical outcome in patients with non-small cell lung cancer （NSCLC） receiving platinum-based chemotherapy. Methods The mRNA expression of ERCC1 in formalin-fixed paraffin-embedded primary tumor specimens was measured by real-time quantitative reverse transcriptase polymerase chain reaction. The association between ERCC1 expression levels and clinicopathological parameters in NSCLC patients was analyzed. Results The median value of ERCC1 mRNA expression level compared with β-actin in tumor specimens of 61 NSCLC patients was 0.48. There was no correlation between ERCCI expression and clinicopathological parameters. Patients with low expression of ERCCI mRNA （ less than 0.35, 0.28, respectively） had a significantly longer median time to progression （TTP） （ 14.3 vs. 8.0 months, P = 0. 028 ） and overall survival （OS） （28.4 vs. 12.9 months, P = 0.0064） than those with high expression. Multivariate analysis showed that a low ERCC1 mRNA expression was an independent factor for OS. Conclusion Our findings suggest that intratumoral ERCC1 mRNA expression level, although is uncorrelated with clinicopathological parameters, is an independent predictive marker for survival of the patients with NSCLC receiving platinum-based chemotherapy, and may provide critical information for personalized chemotherapy.Key words: ERCC1 ; Carcinoma, non-small cell lung; Chemotherapy; Platinum" @default.
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- W2460398187 date "2009-01-01" @default.
- W2460398187 modified "2023-09-22" @default.
- W2460398187 title "Prognostic significance of ERCC1 mRNA expression in patients with non-small cell lung cancer receiving platinum-based chemotherapy" @default.
- W2460398187 doi "https://doi.org/10.3760/cma.j.issn.0253-3766.2009.01.008" @default.
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