FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460466663> ?p ?o ?g. }

• W2460466663 endingPage "531" @default.
• W2460466663 startingPage "519" @default.
• W2460466663 abstract "Rationale: Endothelial Notch signaling is critical for early vascular development and survival. Yet, previously described mice lacking endothelial a disintegrin and metalloproteinase 10 (ADAM10), a key regulator of Notch signaling, survived into adulthood with organ-specific vascular defects. These findings raised questions about whether these vascular defects were related to Notch signaling or other functions of ADAM10. Objective: The aims of the study are to determine whether compensatory or redundant functions of ADAM17 in Notch signaling can explain the survival of Adam10 ΔEC mice, explore the contribution of different Tie2-Cre transgenes to the differences in survival, and establish whether the Adam10 ΔEC vascular phenotypes can be recapitulated by inactivation of Notch receptors in endothelial cells. Methods and Results: Mice lacking ADAM10 and ADAM17 in endothelial cells ( Adam10/Adam17 ΔEC), which survived postnatally with organ-specific vascular defects, resembled Adam10 ΔEC mice. In contrast, Adam10 ΔEC mice generated with the Tie2Cre transgene previously used to inactivate endothelial Notch ( Adam10 ΔEC Flv ) died by E10.5. Quantitative polymerase chain reaction analysis demonstrated that Cre-mediated recombination occurs earlier in Adam10 ΔEC Flv mice than in the previously described Adam10 ΔEC mice. Finally, mice lacking endothelial Notch1 ( Notch1 ΔEC) share some organ-specific vascular defects with Adam10 ΔEC mice, whereas Notch4 −/− mice lacking endothelial Notch1 ( Notch1 ΔEC /Notch4 −/− ) had defects in all vascular beds affected in Adam10 ΔEC mice. Conclusions: Our results argue against a major role for ADAM17 in endothelial Notch signaling and clarify the difference in phenotypes of previously described mice lacking ADAM10 or Notch in endothelial cells. Most notably, these findings uncover new roles for Notch signaling in the development of organ-specific vascular beds." @default.
• W2460466663 created "2016-07-22" @default.
• W2460466663 creator A5002458371 @default.
• W2460466663 creator A5005865384 @default.
• W2460466663 creator A5021850400 @default.
• W2460466663 creator A5028985914 @default.
• W2460466663 creator A5045729213 @default.
• W2460466663 creator A5065032302 @default.
• W2460466663 date "2016-08-05" @default.
• W2460466663 modified "2023-10-16" @default.
• W2460466663 title "ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds" @default.
• W2460466663 cites W143420532 @default.
• W2460466663 cites W1491665105 @default.
• W2460466663 cites W1679229092 @default.
• W2460466663 cites W1963788416 @default.
• W2460466663 cites W1969414295 @default.
• W2460466663 cites W1971162717 @default.
• W2460466663 cites W1993913999 @default.
• W2460466663 cites W1997801717 @default.
• W2460466663 cites W2002307675 @default.
• W2460466663 cites W2005157049 @default.
• W2460466663 cites W2014077602 @default.
• W2460466663 cites W2014925513 @default.
• W2460466663 cites W2019007505 @default.
• W2460466663 cites W2032262970 @default.
• W2460466663 cites W2040170596 @default.
• W2460466663 cites W2047470479 @default.
• W2460466663 cites W2053056402 @default.
• W2460466663 cites W2056916102 @default.
• W2460466663 cites W2062240872 @default.
• W2460466663 cites W2072773345 @default.
• W2460466663 cites W2073429071 @default.
• W2460466663 cites W2082025181 @default.
• W2460466663 cites W2082133442 @default.
• W2460466663 cites W2087363756 @default.
• W2460466663 cites W2094935740 @default.
• W2460466663 cites W2095002343 @default.
• W2460466663 cites W2095550925 @default.
• W2460466663 cites W2095666604 @default.
• W2460466663 cites W2099748390 @default.
• W2460466663 cites W2100979164 @default.
• W2460466663 cites W2105469517 @default.
• W2460466663 cites W2105666413 @default.
• W2460466663 cites W2106527818 @default.
• W2460466663 cites W2113337076 @default.
• W2460466663 cites W2115390024 @default.
• W2460466663 cites W2116173202 @default.
• W2460466663 cites W2116414309 @default.
• W2460466663 cites W2120334345 @default.
• W2460466663 cites W2123478725 @default.
• W2460466663 cites W2128295200 @default.
• W2460466663 cites W2129270491 @default.
• W2460466663 cites W2130727132 @default.
• W2460466663 cites W2135639275 @default.
• W2460466663 cites W2140553945 @default.
• W2460466663 cites W2144026946 @default.
• W2460466663 cites W2144970171 @default.
• W2460466663 cites W2146660065 @default.
• W2460466663 cites W2149152049 @default.
• W2460466663 cites W2150591926 @default.
• W2460466663 cites W2152223912 @default.
• W2460466663 cites W2152877944 @default.
• W2460466663 cites W2157288494 @default.
• W2460466663 cites W2157930949 @default.
• W2460466663 cites W2164394269 @default.
• W2460466663 cites W2605187236 @default.
• W2460466663 cites W2912349604 @default.
• W2460466663 doi "https://doi.org/10.1161/circresaha.115.307738" @default.
• W2460466663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4975635" @default.
• W2460466663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27354212" @default.
• W2460466663 hasPublicationYear "2016" @default.
• W2460466663 type Work @default.
• W2460466663 sameAs 2460466663 @default.
• W2460466663 citedByCount "36" @default.
• W2460466663 countsByYear W24604666632017 @default.
• W2460466663 countsByYear W24604666632018 @default.
• W2460466663 countsByYear W24604666632019 @default.
• W2460466663 countsByYear W24604666632020 @default.
• W2460466663 countsByYear W24604666632021 @default.
• W2460466663 countsByYear W24604666632022 @default.
• W2460466663 countsByYear W24604666632023 @default.
• W2460466663 crossrefType "journal-article" @default.
• W2460466663 hasAuthorship W2460466663A5002458371 @default.
• W2460466663 hasAuthorship W2460466663A5005865384 @default.
• W2460466663 hasAuthorship W2460466663A5021850400 @default.
• W2460466663 hasAuthorship W2460466663A5028985914 @default.
• W2460466663 hasAuthorship W2460466663A5045729213 @default.
• W2460466663 hasAuthorship W2460466663A5065032302 @default.
• W2460466663 hasBestOaLocation W24604666631 @default.
• W2460466663 hasConcept C102230213 @default.
• W2460466663 hasConcept C104317684 @default.
• W2460466663 hasConcept C109523444 @default.
• W2460466663 hasConcept C127716648 @default.
• W2460466663 hasConcept C141035611 @default.
• W2460466663 hasConcept C161879069 @default.
• W2460466663 hasConcept C170493617 @default.
• W2460466663 hasConcept C2778259572 @default.
• W2460466663 hasConcept C2778715156 @default.

• next