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• W2460508744 abstract "A B S T RA C T The in vitro cytotoxic function and target cell specificity of peripheral blood lymphocytes from selected patients with primary biliary cirrhosis and hepatitis B surface antigen-negative chronic hepatitis were investigated using 5'Cr-labeled human Chang and EL-4 mouse sarcoma cell targets in assays of spontaneous cell-mediated cytotoxicity (SCMC) and mitogen-induced cellular cytotoxicity (MICC). In addition, antibody-dependent cellular cytotoxicity (ADCC) against Chang cells was assessed. At an effector-totarget cell ratio of 100:1, the mean SCMC against Chang cells was much less in patients with primary biliary cirrhosis than that in either the controls (P < 0.001) or the patients with chronic hepatitis (P < 0.005) whereas the value for patients with chronic hepatitis did not differ significantly from that ofthe controls. The mean SCMC against EL-4 mouse sarcoma cells was also less in patients with primary biliary cirrhosis than in the controls (P < 0.005) whereas the value for chronic hepatitis was not significantly different from that of the controls or patients with primary biliary cirrhosis. In contrast, MICC against both targets and ADCC against Chang cells were similar for each group. Comparison of SCMC and MICC against both target cells, measured simultaneously, showed similar cytotoxic potential against both target cells for each group. Effector cells capable of mediating cytotoxicity in each assay were defined by testing the cytotoxic function of lymphocyte subpopulations isolated from" @default.
• W2460508744 created "2016-07-22" @default.
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• W2460508744 date "1977-01-01" @default.
• W2460508744 modified "2023-09-27" @default.
• W2460508744 title "In Vitro Cell-Mediated Cytotoxicity in Primary Biliary Cirrhosis and Chronic Hepatitis DYSFUNCTION OF SPONTANEOUS CELL-MEDIATED CYTOTOXICITY" @default.
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