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• W2460547088 abstract "Background: Endothelial dysfunction predicts cardiovascular events and represents an underlying event for vascular abnormalities observed in type 2 diabetes mellitus (T2DM) patients. Vascular endothelial dysfunction is an early marker of atherosclerosis seen in T2DM. It is suggested that-endothelial dysfunction and injury in the vascular wall are repaired by bone marrow-derived endothelial progenitor cells (BM-derived EPCs). Endothelial progenitor cells (EPCs) are mobilized from BM into the peripheral blood in response to tissue ischemia or injury. Aim of the work: This study was designed to assess the relationship of circulating EPCs and endothelial dysfunction in T2DM. Patients: After departmental ethics committee approval and participants consent were obtained, 60 diabetic patients having variable duration of T2DM (group-I) and 30 healthy persons (group-II) with matched age and sex were enrolled in the study. Methods: All participants were subjected to: Detailed history taking, full clinical examination and laboratory studies including; fasting and 2-hour-post-prandial plasma glucose (FPG and PPPG), glycated hemoglobin A1c (HbA1c), lipids profiles, quantification of circulating (EPCs) with flow-cytometry, assessment of vascular endothelial function with flow-mediated dilatation percentage (FMD%) of the brachial artery with a high-resolution ultrasound system. All studied parameters were collected and analyzed statistically using SPSS version 12. Results: Group I (diabetics): 60 T2DM patients with variable duration of DM ranged between 1 and 10 years (33 females and 27 males); their age ranged between 35 and 66 years old. Group II (controls): 30 healthy persons (15 females, 15 males); their age ranged between 30 and 65 years old. The obtained results showed that, Significant increase of systolic, diastolic blood pressures and lipid profiles in diabetics compared with controls. However, significant decrease in EPCs (CD34+, CD133+, and CD34 + CD133+) and FMD% in diabetics compared with controls (P < 0.05). In diabetics, there were inverse correlations between CD34+ counts and advancing age of patients (r = - 0.400; P < 0.05), total cholesterol (r = - 0.294; P < 0.05), FPG (- 0.578; P < 0.05), 2h-PPPG (- 0.474; P < 0.05), HbA1c (- 0.449; P < 0.05) and duration of DM (r = - 0.381; P < 0.05). CD34+ counts had significant positive correlation with FMD% of diabetics (r = 0.565; P < 0.05), Similarly, CD133+ and CD34+ CD133+ counts had the same correlations. FMD% had significant inverse correlations with age (r = - 0.501; P < 0.05), duration of DM (r = - 0.562; P < 0.05), LDL (r = - 0.309; P < 0.05) and markers of glycemic control (FPG (- 0.582; P < 0.05), PPPG (-0.521; P < 0.05) and HbA1c (- 0.339; P < 0.05)); all of these in diabetics point to poor glycemic control, advancing age and duration of DM were associated with more impaired endothelial function. Conclusions: Patients with T2DM had close relationship between reducing numbers of circulating EPCs and the degree of endothelial dysfunction independent of traditional cardiovascular risk factors. Quantification of EPCs counts might be considered as a reliable diagnostic modality for early detection of vascular complications in asymptomatic T2DM patients." @default.
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• W2460547088 date "2016-01-01" @default.
• W2460547088 modified "2023-09-28" @default.
• W2460547088 title "Study of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Type 2 Diabetes Mellitus Patients" @default.
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