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- W2460570346 abstract "Two male volunteers were given metolazone, a new diuretic, intravenously during a stable protracted water diuresis. The drug caused a mean decrease in CH2O of 2.8 c.c. per minute, a mean increase in sodium excretion of 419.5 μEq. per minute and no Significant change in urine flow rate or clearance of either inulin or PAH. The data suggested that metolazone affects the diluting segment of the nephron reducing the ability to clear free water. Five volunteers were given a standard water load with and without metolazone 10 mg. orally. The data revealed that total free water cleared in the 4 hours following the administration of water decreased (387.6 C.c. S.E. ± 73.9, P < 0.02), while osmols cleared increased (546.6 C.c., S.E. ± 106.7, P < 0.01) and sodium excretion increased (60.6 mEq., S.E. ± 10.5, P < 0.01). Urine volumes and potassium excretion were unchanged. Similar studies with oral water loads given to 4 volunteers who were also given 50 mg. of hydrochlorothiazide, which acts on the diluting segment of the nephron, produced changes such as those seen with metolazone. The data suggest, therefore, that metolazone, like hydrochlorothiazide, acts on the diluting segment of the nephron and that the standard oral water load is an accurate and convenient means of determining the site of action of diuretics." @default.
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- W2460570346 date "1970-11-01" @default.
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- W2460570346 title "Standard oral water load to determine the site of action of diuretics in man With data on metolazone, a new diuretic" @default.
- W2460570346 doi "https://doi.org/10.1002/cpt1970116821" @default.
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