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- W246061512 abstract "This chapter provides an overview of techniques for detection of viral antibody. There are numerous serological techniques used to diagnose viral infections. These techniques may be used to accurately identify an unknown virus isolate utilizing a known reference antibody, or may utilize a panel of known viral antigens to test for viral antibody in a patient suspected of having a disease of viral etiology. A fourfold or greater increase in antibody titer is required for diagnosis of infection. These assays can be used to determine the effectiveness of viral vaccines by quantifying the specific antibody response following administration of the vaccine and booster vaccination. The World Health Organization uses these techniques to monitor the incidence of influenza virus throughout the world. The hemagglutination-inhibition antibody assay is useful to study the antigenic variation occurring constantly with the influenza viruses. Diagnostic virology utilizes the following techniques, either singly or in combination, to accurately identify a viral isolate, determine the antigenic relationship of different viral isolates, and to identify and quantify viral antibody: virus neutralization, hemagglutination-inhibition, immunofluorescence, enzyme-linked immunosorbent assay, complement fixation, immunoelectron microscopy immunodiffusion, counter- immuno-electrophoresis radioimmunoassay, immuno- peroxidase staining, single radial immunodiffusion, hemolysis in gel and immune adherence hemagglutination." @default.
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- W246061512 date "1992-01-01" @default.
- W246061512 modified "2023-10-16" @default.
- W246061512 title "INTRODUCTION TO TECHNIQUES FOR DETECTION OF VIRAL ANTIBODY" @default.
- W246061512 doi "https://doi.org/10.1016/b978-0-12-144730-4.50029-1" @default.
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